Thromboxane A2 modulates interaction of dendritic cells and T cells and regulates acquired immunity

Kenji Kabashima, Takahiko Murata, Hiroyuki Tanaka, Toshiyuki Matsuoka, Daiji Sakata, Nobuaki Yoshida, Koko Katagiri, Tatsuo Kinashi, Toshiyuki Tanaka, Masayuki Miyasaka, Hiroichi Nagai, Fumitaka Ushikubi, Shuh Narumiya

研究成果: Contribution to journalArticle査読

137 被引用数 (Scopus)

抄録

Physical interaction of T cells and dendritic cells (DCs) is essential for T cell proliferation and differentiation, but it has been unclear how this interaction is regulated physiologically. Here we show that DCs produce thromboxane A2 (TXA2), whereas naive T cells express the thromboxane receptor (TP). In vitro, a TP agonist enhances random cell movement (chemokinesis) of naive but not memory T cells, impairs DC-T cell adhesion, and inhibits DC-dependent proliferation of T cells. In vivo, immune responses to foreign antigens are enhanced in TP-deficient mice, which also develop marked lymphadenopathy with age. Similar immune responses were seen in wild-type mice treated with a TP antagonist during the sensitization period. Thus, TXA2-TP signaling modulates acquired immunity by negatively regulating DC-T cell interactions.

本文言語英語
ページ(範囲)694-701
ページ数8
ジャーナルNature Immunology
4
7
DOI
出版ステータス出版済み - 7 1 2003
外部発表はい

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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