Thymus-dependent modulation of Ly49 inhibitory receptor expression on NK1.1+ γ/δ T cells

T. Hara, H. Nishimura, Y. Hasegawa, Y. Yoshikai

    研究成果: Contribution to journalArticle

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    Major histocompatibility complex (MHC) class I-specific inhibitory receptors are expressed not only on natural killer (NK) cells but also on some subsets of T cells. We here show Ly49 expression on γ/δ T cells in the thymus and liver of β2-microglobulin-deficient (β2m-/-) and C57BL/6 (β2m+/+) mice. Ly49C/I or Ly49A receptor was expressed on NK1.1+γ/δ T cells but not on NK1.1-γ/δ T cells. The numbers of NK1.1+γ/δ T cells were significantly smaller in β2m+/+ mice than in β2m-/- mice with the same H-2b genetic background. Among NK1.1+γ/δ T cells, the proportions of Ly49C/I + cells but not of Ly49A + cells, were decreased in β2m+/+ mice, suggesting that cognate interaction between Ly49C/I and H-2Kb is involved in the reduction of the number of Ly49C/I +γ/δ T cells in β2m +/+ mice. The frequency of Ly49C/I + cells in NK1.1 +γ/δ T cells was lower in both lethally irradiated β2m+/+ mice transplanted with bone marrow (BM) from β2m-/- mice and lethally irradiated β2m-/- mice transplanted with BM from β2m+/+ mice than those in adult thymectomized BM-transplanted chimera mice. These results suggest that reduction of Ly49C/I+ NK1.1+γ/δ T cells in β2m+/+ mice is at least partly due to the down-modulation by MHC class I molecules on BM-derived haematopoietic cells or radioresistant cells in the thymus.

    元の言語英語
    ページ(範囲)24-30
    ページ数7
    ジャーナルImmunology
    102
    発行部数1
    DOI
    出版物ステータス出版済み - 2001

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Immunology

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