Time-dependent changes in the plasma amino acid concentration in diabetes mellitus

Taiga Mochida, Takayuki Tanaka, Yasuko Shiraki, Hiroko Tajiri, Shirou Matsumoto, Kazutaka Shimbo, Toshihiko Ando, Kimitoshi Nakamura, Masahiro Okamoto, Fumio Endo

研究成果: Contribution to journalArticle査読

24 被引用数 (Scopus)

抄録

We investigated longitudinal change in the amino acid (AA) profile in type 1 diabetes mellitus (DM) using AKITA mice, which develop DM as a result of insulin deficiency. The plasma concentrations of valine, leucine, isoleucine, as well as the total branched chain amino acids, alanine, citrulline and proline, were significantly higher in the diabetic mice. We show that the degree and timing of the changes were different among the plasma amino acid concentrations (pAAs) during the development of type 1 DM.

本文言語英語
ページ(範囲)406-409
ページ数4
ジャーナルMolecular Genetics and Metabolism
103
4
DOI
出版ステータス出版済み - 8 1 2011

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Endocrinology

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