Time to be versatile: Regulation of the replication timing program in budding yeast

Kazumasa Yoshida, Ana Poveda, Philippe Pasero

研究成果: Contribution to journalReview article査読

25 被引用数 (Scopus)

抄録

Eukaryotic replication origins are activated at different times during the S phase of the cell cycle, following a temporal program that is stably transmitted to daughter cells. Although the mechanisms that control initiation at the level of individual origins are now well understood, much less is known on how cells coordinate replication at hundreds of origins distributed on the chromosomes. In this review, we discuss recent advances shedding new light on how this complex process is regulated in the budding yeast Saccharomyces cerevisiae. The picture that emerges from these studies is that replication timing is regulated in cis by mechanisms modulating the chromatin structure and the subnuclear organization of origins. These mechanisms do not affect the licensing of replication origins but determine their ability to compete for limiting initiation factors, which are recycled from early to late origins throughout the length of the S phase.

本文言語英語
ページ(範囲)4696-4705
ページ数10
ジャーナルJournal of Molecular Biology
425
23
DOI
出版ステータス出版済み - 11 29 2013

All Science Journal Classification (ASJC) codes

  • 構造生物学
  • 分子生物学

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