抄録
Eukaryotic replication origins are activated at different times during the S phase of the cell cycle, following a temporal program that is stably transmitted to daughter cells. Although the mechanisms that control initiation at the level of individual origins are now well understood, much less is known on how cells coordinate replication at hundreds of origins distributed on the chromosomes. In this review, we discuss recent advances shedding new light on how this complex process is regulated in the budding yeast Saccharomyces cerevisiae. The picture that emerges from these studies is that replication timing is regulated in cis by mechanisms modulating the chromatin structure and the subnuclear organization of origins. These mechanisms do not affect the licensing of replication origins but determine their ability to compete for limiting initiation factors, which are recycled from early to late origins throughout the length of the S phase.
| 元の言語 | 英語 |
|---|---|
| ページ（範囲） | 4696-4705 |
| ページ数 | 10 |
| ジャーナル | Journal of Molecular Biology |
| 巻 | 425 |
| 発行部数 | 23 |
| DOI | |
| 出版物ステータス | 出版済み - 11 29 2013 |
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All Science Journal Classification (ASJC) codes
- Structural Biology
- Molecular Biology
これを引用
Time to be versatile : Regulation of the replication timing program in budding yeast. / Yoshida, Kazumasa; Poveda, Ana; Pasero, Philippe.
：: Journal of Molecular Biology, 巻 425, 番号 23, 29.11.2013, p. 4696-4705.研究成果: ジャーナルへの寄稿 › 評論記事
}
TY - JOUR
T1 - Time to be versatile
T2 - Regulation of the replication timing program in budding yeast
AU - Yoshida, Kazumasa
AU - Poveda, Ana
AU - Pasero, Philippe
PY - 2013/11/29
Y1 - 2013/11/29
N2 - Eukaryotic replication origins are activated at different times during the S phase of the cell cycle, following a temporal program that is stably transmitted to daughter cells. Although the mechanisms that control initiation at the level of individual origins are now well understood, much less is known on how cells coordinate replication at hundreds of origins distributed on the chromosomes. In this review, we discuss recent advances shedding new light on how this complex process is regulated in the budding yeast Saccharomyces cerevisiae. The picture that emerges from these studies is that replication timing is regulated in cis by mechanisms modulating the chromatin structure and the subnuclear organization of origins. These mechanisms do not affect the licensing of replication origins but determine their ability to compete for limiting initiation factors, which are recycled from early to late origins throughout the length of the S phase.
AB - Eukaryotic replication origins are activated at different times during the S phase of the cell cycle, following a temporal program that is stably transmitted to daughter cells. Although the mechanisms that control initiation at the level of individual origins are now well understood, much less is known on how cells coordinate replication at hundreds of origins distributed on the chromosomes. In this review, we discuss recent advances shedding new light on how this complex process is regulated in the budding yeast Saccharomyces cerevisiae. The picture that emerges from these studies is that replication timing is regulated in cis by mechanisms modulating the chromatin structure and the subnuclear organization of origins. These mechanisms do not affect the licensing of replication origins but determine their ability to compete for limiting initiation factors, which are recycled from early to late origins throughout the length of the S phase.
UR - http://www.scopus.com/inward/record.url?scp=84887403791&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84887403791&partnerID=8YFLogxK
U2 - 10.1016/j.jmb.2013.09.020
DO - 10.1016/j.jmb.2013.09.020
M3 - Review article
C2 - 24076190
AN - SCOPUS:84887403791
VL - 425
SP - 4696
EP - 4705
JO - Journal of Molecular Biology
JF - Journal of Molecular Biology
SN - 0022-2836
IS - 23
ER -