TY - JOUR
T1 - Tissue culture on a chip
T2 - Developmental biology applications of self-organized capillary networks in microfluidic devices
AU - Miura, Takashi
AU - Yokokawa, Ryuji
N1 - Publisher Copyright:
© 2016 Japanese Society of Developmental Biologists
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Organ culture systems are used to elucidate the mechanisms of pattern formation in developmental biology. Various organ culture techniques have been used, but the lack of microcirculation in such cultures impedes the long-term maintenance of larger tissues. Recent advances in microfluidic devices now enable us to utilize self-organized perfusable capillary networks in organ cultures. In this review, we will overview past approaches to organ culture and current technical advances in microfluidic devices, and discuss possible applications of microfluidics towards the study of developmental biology.
AB - Organ culture systems are used to elucidate the mechanisms of pattern formation in developmental biology. Various organ culture techniques have been used, but the lack of microcirculation in such cultures impedes the long-term maintenance of larger tissues. Recent advances in microfluidic devices now enable us to utilize self-organized perfusable capillary networks in organ cultures. In this review, we will overview past approaches to organ culture and current technical advances in microfluidic devices, and discuss possible applications of microfluidics towards the study of developmental biology.
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U2 - 10.1111/dgd.12292
DO - 10.1111/dgd.12292
M3 - Review article
C2 - 27272910
AN - SCOPUS:84978811122
VL - 58
SP - 505
EP - 515
JO - Development Growth and Differentiation
JF - Development Growth and Differentiation
SN - 0012-1592
IS - 6
ER -