Tissue distribution of antihypertensive dipeptide, Val-Tyr, after its single oral administration to spontaneously hypertensive rats

Toshiro Matsui, Miho Imamura, Hiromi Oka, Katsuhiro Osajima, Ko Ichi Kimoto, Terukazu Kawasaki, Kiyoshi Matsumoto

研究成果: ジャーナルへの寄稿学術誌査読

72 被引用数 (Scopus)

抄録

The distribution of an antihypertensive dipeptide, Val-Tyr (VY), in the tissues of spontaneously hypertensive rats (SHR) was investigated in this study. A single oral administration of VY (10 mg/kg) to 18-week-old SHR resulted in a prolonged reduction of systolic blood pressure (SBP) up to 9 h (SBP0h 198.0 ± 3.6 mmHg; SBP9h 154.6 ± 3.5 mmHg). As a result of VY determination, a roughly 10-fold higher increment of plasma VY level was observed at 1 h than that at 0 h, whereas thereafter the level declined rapidly. In tissues, VY was widely accumulated in the kidney, lung, heart, mesenteric artery and abdominal aorta with the area under the curve over 9 h of more than 40 pmol h/g tissue; of these a higher VY level was observed in the kidney and lung. In addition, a mean resident time (MRT) for each tissue (>5 h except for liver) revealed that VY preferably accumulated in the tissues rather than in the plasma (MRT 3.8 h). Significant reductions of tissue angiotensin I-converting enzyme activity and angiotensin II level were found in the abdominal aorta as well as in the kidney, suggesting that these organs could be a target site associated with the antihypertensive action of VY.

本文言語英語
ページ(範囲)535-545
ページ数11
ジャーナルJournal of Peptide Science
10
9
DOI
出版ステータス出版済み - 9月 2004

All Science Journal Classification (ASJC) codes

  • 構造生物学
  • 生化学
  • 分子医療
  • 分子生物学
  • 薬理学
  • 創薬
  • 有機化学

フィンガープリント

「Tissue distribution of antihypertensive dipeptide, Val-Tyr, after its single oral administration to spontaneously hypertensive rats」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル