Tissue responses to anti-washout apatite cement using chitosan when implanted in the rat tibia

M. Takechi, K. Ishikawa, Y. Miyamoto, M. Nagayama, K. Suzuki

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The tissue response to anti-washout apatite cement using chitosan (aw-AC(chi)) was evaluated by implanting aw-AC(chi) into bone defects of rat tibiae using conventional apatite cement (c-AC) as a control material. During the experimental period up to 16 weeks, the only difference between aw-AC and c-AC was found at two weeks in the tissue response of soft tissue. At two weeks, c-AC showed a moderate inflammatory response; small particles of c-AC were scattered in the cutaneous tissue and many foreign body giant cells were collected around the scattered c-AC, whereas aw-AC showed only a slight inflammatory response and few foreign body giant cells. We found no difference between aw-AC(chi) and c-AC with respect to bone tissue response. Both AC were almost completely surrounded by mature bone at eight weeks. No promotion or reduction of osteoconductivity was observed by chitosan even though it is considered to promote bone formation. We concluded, 1therefore, that enhancement of bone formation cannot be expected by employing chitosan to obtain anti-washout properties, at least in the concentration used in this study, even though aw-AC(chi) is much more useful than c-AC.

元の言語英語
ページ(範囲)597-602
ページ数6
ジャーナルJournal of Materials Science: Materials in Medicine
12
発行部数7
DOI
出版物ステータス出版済み - 8 7 2001
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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