Tissue-specific distribution of genistein, daidzein and bisphenol A in male Sprague-Dawley rats after intragastric administration

Shin Yasuda, Po Sheng Wu, Masaaki Okabe, Hirofumi Tachibana, Koji Yamada

研究成果: Contribution to journalReview article査読

抄録

A mixture of genistein, daidzein and bisphenol A was intragastrically given to male Sprague-Dawley rats. The tissue distribution of these compounds and equol, a metabolite of daidzein, was examined by high-performance liquid chromatography after administration. In the serum, liver and kidney, genistein, daidzein and bisphenol A were clearly detected at 6 to 24h. Equol was detected at Oh and levels subsequently dropped and then increased again, reaching the initial level at 24 h. In the mesenteric lymph node (MLN), thymus and spleen, genistein and daidzein were detected at 6 to 24 h. Bisphenol A and equol in the MLN was detectable at 6 to 24 h and 24 h, respectively. In the testicle, epididymis, spermatheca and prostate, higher levels of genistein and daidzein were detected around 6 h. Bisphenol A was detected in the epididymis at 6 to 12 h. These results suggest that the distribution of these chemicals and their tissue affinities in rats vary from tissue to tissue.

本文言語英語
ページ(範囲)187-193
ページ数7
ジャーナルFood Science and Technology Research
11
2
DOI
出版ステータス出版済み - 5 1 2005

All Science Journal Classification (ASJC) codes

  • バイオテクノロジー
  • 食品科学
  • 化学工学(全般)
  • 産業および生産工学
  • マーケティング

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