Topographic mapping--the olfactory system.

Takeshi Imai, Hitoshi Sakano, Leslie B. Vosshall

研究成果: Contribution to journalReview article査読

53 被引用数 (Scopus)

抄録

Sensory systems must map accurate representations of the external world in the brain. Although the physical senses of touch and vision build topographic representations of the spatial coordinates of the body and the field of view, the chemical sense of olfaction maps discontinuous features of chemical space, comprising an extremely large number of possible odor stimuli. In both mammals and insects, olfactory circuits are wired according to the convergence of axons from sensory neurons expressing the same odorant receptor. Synapses are organized into distinctive spherical neuropils--the olfactory glomeruli--that connect sensory input with output neurons and local modulatory interneurons. Although there is a strong conservation of form in the olfactory maps of mammals and insects, they arise using divergent mechanisms. Olfactory glomeruli provide a unique solution to the problem of mapping discontinuous chemical space onto the brain.

本文言語英語
ページ(範囲)a001776
ジャーナルCold Spring Harbor Perspectives in Biology
2
8
DOI
出版ステータス出版済み - 8 1 2010
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学、遺伝学、分子生物学(全般)

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