抄録
Sensory systems must map accurate representations of the external world in the brain. Although the physical senses of touch and vision build topographic representations of the spatial coordinates of the body and the field of view, the chemical sense of olfaction maps discontinuous features of chemical space, comprising an extremely large number of possible odor stimuli. In both mammals and insects, olfactory circuits are wired according to the convergence of axons from sensory neurons expressing the same odorant receptor. Synapses are organized into distinctive spherical neuropils--the olfactory glomeruli--that connect sensory input with output neurons and local modulatory interneurons. Although there is a strong conservation of form in the olfactory maps of mammals and insects, they arise using divergent mechanisms. Olfactory glomeruli provide a unique solution to the problem of mapping discontinuous chemical space onto the brain.
| 元の言語 | 英語 |
|---|---|
| ジャーナル | Cold Spring Harbor Perspectives in Biology |
| 巻 | 2 |
| 発行部数 | 8 |
| DOI | |
| 出版物ステータス | 出版済み - 8 1 2010 |
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All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
これを引用
Topographic mapping--the olfactory system. / Imai, Takeshi; Sakano, Hitoshi; Vosshall, Leslie B.
：: Cold Spring Harbor Perspectives in Biology, 巻 2, 番号 8, 01.08.2010.研究成果: ジャーナルへの寄稿 › 評論記事
}
TY - JOUR
T1 - Topographic mapping--the olfactory system.
AU - Imai, Takeshi
AU - Sakano, Hitoshi
AU - Vosshall, Leslie B.
PY - 2010/8/1
Y1 - 2010/8/1
N2 - Sensory systems must map accurate representations of the external world in the brain. Although the physical senses of touch and vision build topographic representations of the spatial coordinates of the body and the field of view, the chemical sense of olfaction maps discontinuous features of chemical space, comprising an extremely large number of possible odor stimuli. In both mammals and insects, olfactory circuits are wired according to the convergence of axons from sensory neurons expressing the same odorant receptor. Synapses are organized into distinctive spherical neuropils--the olfactory glomeruli--that connect sensory input with output neurons and local modulatory interneurons. Although there is a strong conservation of form in the olfactory maps of mammals and insects, they arise using divergent mechanisms. Olfactory glomeruli provide a unique solution to the problem of mapping discontinuous chemical space onto the brain.
AB - Sensory systems must map accurate representations of the external world in the brain. Although the physical senses of touch and vision build topographic representations of the spatial coordinates of the body and the field of view, the chemical sense of olfaction maps discontinuous features of chemical space, comprising an extremely large number of possible odor stimuli. In both mammals and insects, olfactory circuits are wired according to the convergence of axons from sensory neurons expressing the same odorant receptor. Synapses are organized into distinctive spherical neuropils--the olfactory glomeruli--that connect sensory input with output neurons and local modulatory interneurons. Although there is a strong conservation of form in the olfactory maps of mammals and insects, they arise using divergent mechanisms. Olfactory glomeruli provide a unique solution to the problem of mapping discontinuous chemical space onto the brain.
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U2 - 10.1101/cshperspect.a001776
DO - 10.1101/cshperspect.a001776
M3 - Review article
C2 - 20554703
AN - SCOPUS:78349286342
VL - 2
JO - Cold Spring Harbor perspectives in biology
JF - Cold Spring Harbor perspectives in biology
SN - 1943-0264
IS - 8
ER -