Total left ventricular unloading markedly reduces the pressure-volume area, thereby oxygen consumption

Takahiro Arimura, Keita Saku, Takamori Kakino, Takuya Akashi, Takako Takehara, Akiko Nishizaki, Yasuhiro Oga, Masataka Ikeda, Kana Fujii, Tomomi Ide, Takuya Kishi, Kenji Sunagawa

研究成果: Contribution to journalArticle査読

抄録

Left ventricular assist device (LVAD) unloads LV and exerts better outcome in both acute coronary syndrome and severe heart failure. In this study, we investigate how the degree of LVAD support impacts on the hemodynamics and oxygen consumption of left ventricle. Methods/Results: We used 5 dogs and changed LVAD support at 3 levels, no support, Partial (LV remains ejecting) and Total (total LVAD dependent circulation). Mean aortic pressure were not different among 3 groups, while peak systolic pressure of LV reduced in Total (108±8.6 vs 102±3.3 vs 42±11mmHg, p<0.05). The pressure-volume area (PVA) indicating oxygen consumption of LV significantly reduced in Partial, while markedly reduced in Total (2040±632 vs 1787±547 vs 487±160 ml·mmHg, p<0.05). Conclusions: Total unloading minimizes oxygen consumption of left ventricle. Appropriate unloading minimizes oxygen consumption and enables us to maximize the beneficial effect of LVAD in heart disease.

本文言語英語
ページ(範囲)O-548-O-549
ジャーナルTransactions of Japanese Society for Medical and Biological Engineering
52
DOI
出版ステータス出版済み - 8 17 2014

All Science Journal Classification (ASJC) codes

  • 生体医工学

フィンガープリント

「Total left ventricular unloading markedly reduces the pressure-volume area, thereby oxygen consumption」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル