TY - JOUR
T1 - Total left ventricular unloading markedly reduces the pressure-volume area, thereby oxygen consumption
AU - Arimura, Takahiro
AU - Saku, Keita
AU - Kakino, Takamori
AU - Akashi, Takuya
AU - Takehara, Takako
AU - Nishizaki, Akiko
AU - Oga, Yasuhiro
AU - Ikeda, Masataka
AU - Fujii, Kana
AU - Ide, Tomomi
AU - Kishi, Takuya
AU - Sunagawa, Kenji
N1 - Publisher Copyright:
© 2014, Japan Soc. of Med. Electronics and Biol. Engineering. All rights reserved.
PY - 2014/8/17
Y1 - 2014/8/17
N2 - Left ventricular assist device (LVAD) unloads LV and exerts better outcome in both acute coronary syndrome and severe heart failure. In this study, we investigate how the degree of LVAD support impacts on the hemodynamics and oxygen consumption of left ventricle. Methods/Results: We used 5 dogs and changed LVAD support at 3 levels, no support, Partial (LV remains ejecting) and Total (total LVAD dependent circulation). Mean aortic pressure were not different among 3 groups, while peak systolic pressure of LV reduced in Total (108±8.6 vs 102±3.3 vs 42±11mmHg, p<0.05). The pressure-volume area (PVA) indicating oxygen consumption of LV significantly reduced in Partial, while markedly reduced in Total (2040±632 vs 1787±547 vs 487±160 ml·mmHg, p<0.05). Conclusions: Total unloading minimizes oxygen consumption of left ventricle. Appropriate unloading minimizes oxygen consumption and enables us to maximize the beneficial effect of LVAD in heart disease.
AB - Left ventricular assist device (LVAD) unloads LV and exerts better outcome in both acute coronary syndrome and severe heart failure. In this study, we investigate how the degree of LVAD support impacts on the hemodynamics and oxygen consumption of left ventricle. Methods/Results: We used 5 dogs and changed LVAD support at 3 levels, no support, Partial (LV remains ejecting) and Total (total LVAD dependent circulation). Mean aortic pressure were not different among 3 groups, while peak systolic pressure of LV reduced in Total (108±8.6 vs 102±3.3 vs 42±11mmHg, p<0.05). The pressure-volume area (PVA) indicating oxygen consumption of LV significantly reduced in Partial, while markedly reduced in Total (2040±632 vs 1787±547 vs 487±160 ml·mmHg, p<0.05). Conclusions: Total unloading minimizes oxygen consumption of left ventricle. Appropriate unloading minimizes oxygen consumption and enables us to maximize the beneficial effect of LVAD in heart disease.
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U2 - 10.11239/jsmbe.52.O-548
DO - 10.11239/jsmbe.52.O-548
M3 - Article
AN - SCOPUS:84939451350
SN - 1347-443X
VL - 52
SP - O-548-O-549
JO - BME = Bio medical engineering / henshu, Nihon ME Gakkai
JF - BME = Bio medical engineering / henshu, Nihon ME Gakkai
ER -