Total synthesis and chemical biology of the sarcodictyins

K. C. Nicolaou, Jeffrey Pfefferkorn, Jinyou Xu, Nicolas Winssinger, Takashi Ohshima, Sanghee Kim, Seijiro Hosokawa, Dionisios Vourloumis, Floris Van Delft, Tianhu Li

研究成果: Contribution to journalReview article査読

54 被引用数 (Scopus)

抄録

The sarcodictyins A - F and eleutherobin comprise a family of marine- derived diterpenoids with potent cytotoxicities against various tumor cell lines. Investigations have revealed that several of these compounds exert their cytotoxic effects through tubulin binding in a mechanism analogous to that of the clinical anticancer drug Taxol(TM). The biological importance, challenging molecular architecture, and relative scarcity of these natural products have prompted several groups to undertake their total chemical synthesis. In this review, we summarize the current synthetic efforts and examine the preliminary structure-activity relationships which have emerged from early combinatorial libraries.

本文言語英語
ページ(範囲)1199-1213
ページ数15
ジャーナルChemical and Pharmaceutical Bulletin
47
9
DOI
出版ステータス出版済み - 9 1999
外部発表はい

All Science Journal Classification (ASJC) codes

  • 化学 (全般)
  • 創薬

フィンガープリント

「Total synthesis and chemical biology of the sarcodictyins」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル