Total synthesis and chemical biology of the sarcodictyins

K. C. Nicolaou, Jeffrey Pfefferkorn, Jinyou Xu, Nicolas Winssinger, Takashi Ohshima, Sanghee Kim, Seijiro Hosokawa, Dionisios Vourloumis, Floris Van Delft, Tianhu Li

研究成果: Contribution to journalReview article

54 引用 (Scopus)

抜粋

The sarcodictyins A - F and eleutherobin comprise a family of marine- derived diterpenoids with potent cytotoxicities against various tumor cell lines. Investigations have revealed that several of these compounds exert their cytotoxic effects through tubulin binding in a mechanism analogous to that of the clinical anticancer drug Taxol(TM). The biological importance, challenging molecular architecture, and relative scarcity of these natural products have prompted several groups to undertake their total chemical synthesis. In this review, we summarize the current synthetic efforts and examine the preliminary structure-activity relationships which have emerged from early combinatorial libraries.

元の言語英語
ページ(範囲)1199-1213
ページ数15
ジャーナルChemical and Pharmaceutical Bulletin
47
発行部数9
DOI
出版物ステータス出版済み - 9 1999
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

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    Nicolaou, K. C., Pfefferkorn, J., Xu, J., Winssinger, N., Ohshima, T., Kim, S., Hosokawa, S., Vourloumis, D., Van Delft, F., & Li, T. (1999). Total synthesis and chemical biology of the sarcodictyins. Chemical and Pharmaceutical Bulletin, 47(9), 1199-1213. https://doi.org/10.1248/cpb.47.1199