Total synthesis of (-)-brevenal: A concise synthetic entry to the pentacyclic polyether core

Makoto Ebine, Haruhiko Fuwa, Makoto Sasaki

研究成果: Contribution to journalArticle

40 引用 (Scopus)

抜粋

(Chemical Equation Presented) Total synthesis of (-)-brevenal, a novel marine polycyclic ether natural product, is described. Highly efficient and scalable entries to the AB-ring exo-olefin and the DE-ring enol phosphate and a rapid construction of the C-ring by means of our Suzuki-Miyaura coupling-based strategy realized a concise synthesis of the pentacyclic skeleton of (-)-brevenal. The present synthesis is considerably more efficient than our previous synthesis (longest linear sequence: 50 steps from 2-deoxy-D-ribose).

元の言語英語
ページ(範囲)2275-2278
ページ数4
ジャーナルOrganic Letters
10
発行部数11
DOI
出版物ステータス出版済み - 6 5 2008

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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