Total synthesis of ciguatoxin CTX3C

M. Hirama, T. Oishi, H. Uehara, M. Inoue, M. Maruyama, H. Oguri, M. Satake

研究成果: Contribution to journalArticle査読

236 被引用数 (Scopus)

抄録

More than 20,000 people suffer annually from ciguatera seafood poisoning in subtropical and tropical regions. The extremely low content of the causative neurotoxins, designated as ciguatoxins, in fish has hampered the isolation, detailed biological studies, and preparation of anti-ciguatoxin antibodies for detecting these toxins. The large (3 nanometers long) and complicated molecular structure of ciguatoxins has impeded chemists from completing their total synthesis. Our highly convergent strategic approach featuring the chemoselective ring-closing metathesis reaction as a key tactic has enabled the total synthesis of ciguatoxin CTX3C, which will provide a practical supply for further studies.

本文言語英語
ページ(範囲)1904-1907
ページ数4
ジャーナルScience
294
5548
DOI
出版ステータス出版済み - 11 30 2001
外部発表はい

All Science Journal Classification (ASJC) codes

  • 一般

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