Total synthesis of ciguatoxin CTX3C

研究成果: ジャーナルへの寄稿学術誌査読

4 被引用数 (Scopus)

抄録

Ciguatoxins are the causative neurotoxins of ciguatera seafood poisoning, and more than 20,000 people suffer annually from ciguatera disease in subtropical and tropical regions. The extremely low content of ciguatoxins in fish has hampered the isolation and detailed biological studies. The complicated and huge, 3 nm long, molecular structure of ciguatoxins has impeded synthetic chemists from completing their total syntheses, which are formidable synthetic challenge in modern organic synthesis. Our highly convergent strategic approach featuring the chemoselective ring closing metathesis (RCM) reaction as a key tactics, (i) alkylative coupling and RCM, (ii) intramolecular carbonyl olefination and reductive etherification, (iii) chemo- and regioselective radical cyclization and RCM, has enabled the first total synthesis of ciguatoxin CTX 3 C, which will provide the practical supply for further studies.

本文言語英語
ページ(範囲)562-571
ページ数10
ジャーナルYuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
61
6
DOI
出版ステータス出版済み - 6月 2003
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 有機化学

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