Total synthesis of the marine natural products lukianols A and B

Kaoru Takamura, Hisami Matsuo, Ayana Tanaka, Junji Tanaka, Tsutomu Fukuda, Fumito Ishibashi, Masatomo Iwao

研究成果: Contribution to journalArticle査読

14 被引用数 (Scopus)

抄録

Total synthesis of the pyrrolic marine natural products lukianols A (1) and B (2) has been achieved using N-benzenesulfonyl-3,4-dibromopyrrole (3) as a common starting material. The key synthetic strategy developed is the combined bromine-directed lithiation and palladium-catalyzed cross-coupling of 3 to produce 3,4-diarylpyrrol-2-carboxylates. Regioselective iodination of the phenolic intermediate 24 was thoroughly investigated for the synthesis of lukianol B.

本文言語英語
ページ(範囲)2782-2788
ページ数7
ジャーナルTetrahedron
69
13
DOI
出版ステータス出版済み - 4 1 2013

All Science Journal Classification (ASJC) codes

  • 生化学
  • 創薬
  • 有機化学

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