Towards an understanding of the regulatory mechanisms of totipotency

Takashi Ishiuchi, Maria Elena Torres-Padilla

研究成果: Contribution to journalReview article査読

28 被引用数 (Scopus)

抄録

The 21st century started with an important discovery that a pluripotent stem cell can be induced from differentiated cells by 'simply' introducing a few transcription factors. Because pluripotent embryonic stem cells can be stably maintained in culture and also induced, the mechanisms as to how cells maintain and acquire pluripotency have been extensively interrogated. In contrast, how cells maintain or acquire totipotency and the cell potency that exists in the zygote are still poorly understood. To address this question, it is necessary to capture the features that reside in totipotent cells. Here, we review recent results, which shed light on the unique epigenetic state in totipotent cells, and discuss how totipotency is regulated before finding its way towards pluripotency.

本文言語英語
ページ(範囲)512-518
ページ数7
ジャーナルCurrent Opinion in Genetics and Development
23
5
DOI
出版ステータス出版済み - 10 2013
外部発表はい

All Science Journal Classification (ASJC) codes

  • 遺伝学
  • 発生生物学

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