Trans-Omics: How To Reconstruct Biochemical Networks Across Multiple 'Omic' Layers

Katsuyuki Yugi, Hiroyuki Kubota, Atsushi Hatano, Shinya Kuroda

研究成果: Contribution to journalReview article査読

124 被引用数 (Scopus)

抄録

We propose 'trans-omic' analysis for reconstructing global biochemical networks across multiple omic layers by use of both multi-omic measurements and computational data integration. We introduce technologies for connecting multi-omic data based on prior knowledge of biochemical interactions and characterize a biochemical trans-omic network by concepts of a static and dynamic nature. We introduce case studies of metabolism-centric trans-omic studies to show how to reconstruct a biochemical trans-omic network by connecting multi-omic data and how to analyze it in terms of the static and dynamic nature. We propose a trans-ome-wide association study (trans-OWAS) connecting phenotypes with trans-omic networks that reflect both genetic and environmental factors, which can characterize several complex lifestyle diseases as breakdowns in the trans-omic system.

本文言語英語
ページ(範囲)276-290
ページ数15
ジャーナルTrends in biotechnology
34
4
DOI
出版ステータス出版済み - 4 1 2016

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering

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