Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells

Izumi Ohigashi, Yu Tanaka, Kenta Kondo, Sayumi Fujimori, Hiroyuki Kondo, Amy C. Palin, Victoria Hoffmann, Mina Kozai, Yosuke Matsushita, Shinsuke Uda, Ryo Motosugi, Jun Hamazaki, Hiroyuki Kubota, Shigeo Murata, Keiji Tanaka, Toyomasa Katagiri, Hidetaka Kosako, Yousuke Takahama

研究成果: Contribution to journalArticle

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抜粋

Ohigashi et al. show that the use of cyclin D1-transgenic mice allows quantitative proteomic analysis of cortical and medullary thymic epithelial cells (TECs). Results provide a trans-omics platform for further exploration of TEC biology and reveal the specific impact of the thymoproteasome on proteasome subunit composition in cortical TECs.

元の言語英語
ページ(範囲)2901-2916.e6
ジャーナルCell Reports
29
発行部数9
DOI
出版物ステータス出版済み - 11 26 2019

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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    Ohigashi, I., Tanaka, Y., Kondo, K., Fujimori, S., Kondo, H., Palin, A. C., Hoffmann, V., Kozai, M., Matsushita, Y., Uda, S., Motosugi, R., Hamazaki, J., Kubota, H., Murata, S., Tanaka, K., Katagiri, T., Kosako, H., & Takahama, Y. (2019). Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells. Cell Reports, 29(9), 2901-2916.e6. https://doi.org/10.1016/j.celrep.2019.10.079