Transdifferentiation of human somatic cells by ribosome

Naofumi Ito, Mohammad Badrul Anam, Shah Adil Ishtiyaq Ahmad, Kunimasa Ohta

研究成果: Contribution to journalReview article査読

3 被引用数 (Scopus)

抄録

Ribosomes are intracellular organelles ubiquitous in all organisms, which translate information from mRNAs to synthesize proteins. They are complex macromolecules composed of dozens of proteins and ribosomal RNAs. Other than translation, some ribosomal proteins also have side-jobs called “Moonlighting” function. The majority of these moonlighting functions influence cancer progression, early development and differentiation. Recently, we discovered that ribosome is involved in the regulation of cellular transdifferentiation of human dermal fibroblasts (HDFs). In vitro incorporation of ribosomes into HDFs arrests cell proliferation and induces the formation of cell clusters, that differentiate into three germ layer derived cells upon induction by differentiation mediums. The discovery of ribosome induced transdifferentiation, that is not based on genetic modification, find new possibilities for the treatment of cancer and congenital diseases, as well as to understand early development and cellular lineage differentiation.

本文言語英語
ページ(範囲)241-247
ページ数7
ジャーナルDevelopment Growth and Differentiation
60
5
DOI
出版ステータス出版済み - 6 2018
外部発表はい

All Science Journal Classification (ASJC) codes

  • 発生生物学
  • 細胞生物学

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