Transglutaminase in Invertebrates

研究成果: 書籍/レポート タイプへの寄稿

5 被引用数 (Scopus)

抄録

In mammals, transglutaminases play roles in a variety of essential functions, including blood coagulation, skin formation, and signal transduction, by catalyzing the isopeptide bond formation between Lys and Gln residues to form e-(γ-glutamyl) lysine bonds between appropriate substrates. Similarly, in invertebrates, such as the horseshoe crab Tachypleus tridentatus, the crayfish Pacifastacus leniusculus, and the fruit fly Drosophila melanogaster, transglutaminase is conserved and exhibits pleiotropic functions. In 1993, the first report of a nucleotide sequence of the intracellular transglutaminase in T. tridentatus was made. Today, the functions of invertebrate transglutaminases are widely investigated using biochemical and genetic techniques. Here we review the existing knowledge of invertebrate transglutaminases with an emphasis on the importance of various physiological properties in innate immune reactions.

本文言語英語
ホスト出版物のタイトルTransglutaminases
ホスト出版物のサブタイトルMultiple Functional Modifiers and Targets for New Drug Discovery
出版社Springer Japan
ページ117-127
ページ数11
ISBN(電子版)9784431558255
ISBN(印刷版)9784431558231
DOI
出版ステータス出版済み - 1月 1 2016

!!!All Science Journal Classification (ASJC) codes

  • 医学(全般)
  • 生化学、遺伝学、分子生物学(全般)

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