Transglutaminase in Invertebrates

研究成果: 著書/レポートタイプへの貢献

5 引用 (Scopus)

抄録

In mammals, transglutaminases play roles in a variety of essential functions, including blood coagulation, skin formation, and signal transduction, by catalyzing the isopeptide bond formation between Lys and Gln residues to form e-(γ-glutamyl) lysine bonds between appropriate substrates. Similarly, in invertebrates, such as the horseshoe crab Tachypleus tridentatus, the crayfish Pacifastacus leniusculus, and the fruit fly Drosophila melanogaster, transglutaminase is conserved and exhibits pleiotropic functions. In 1993, the first report of a nucleotide sequence of the intracellular transglutaminase in T. tridentatus was made. Today, the functions of invertebrate transglutaminases are widely investigated using biochemical and genetic techniques. Here we review the existing knowledge of invertebrate transglutaminases with an emphasis on the importance of various physiological properties in innate immune reactions.

元の言語英語
ホスト出版物のタイトルTransglutaminases
ホスト出版物のサブタイトルMultiple Functional Modifiers and Targets for New Drug Discovery
出版者Springer Japan
ページ117-127
ページ数11
ISBN(電子版)9784431558255
ISBN(印刷物)9784431558231
DOI
出版物ステータス出版済み - 1 1 2016

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Transglutaminases
Invertebrates
Horseshoe Crabs
Antigen-antibody reactions
Genetic Techniques
Astacoidea
Signal transduction
Mammals
Blood Coagulation
Fruits
Coagulation
Drosophila melanogaster
Diptera
Lysine
Molecular Biology
Signal Transduction
Fruit
Skin
Blood
Nucleotides

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

これを引用

Shibata, T., & Kawabata, S-I. (2016). Transglutaminase in Invertebrates. : Transglutaminases: Multiple Functional Modifiers and Targets for New Drug Discovery (pp. 117-127). Springer Japan. https://doi.org/10.1007/978-4-431-55825-5_5

Transglutaminase in Invertebrates. / Shibata, Toshio; Kawabata, Shun-Ichiro.

Transglutaminases: Multiple Functional Modifiers and Targets for New Drug Discovery. Springer Japan, 2016. p. 117-127.

研究成果: 著書/レポートタイプへの貢献

Shibata, T & Kawabata, S-I 2016, Transglutaminase in Invertebrates. : Transglutaminases: Multiple Functional Modifiers and Targets for New Drug Discovery. Springer Japan, pp. 117-127. https://doi.org/10.1007/978-4-431-55825-5_5
Shibata T, Kawabata S-I. Transglutaminase in Invertebrates. : Transglutaminases: Multiple Functional Modifiers and Targets for New Drug Discovery. Springer Japan. 2016. p. 117-127 https://doi.org/10.1007/978-4-431-55825-5_5
Shibata, Toshio ; Kawabata, Shun-Ichiro. / Transglutaminase in Invertebrates. Transglutaminases: Multiple Functional Modifiers and Targets for New Drug Discovery. Springer Japan, 2016. pp. 117-127
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