Transient Elastography for the prediction of oxaliplatin-associated liver injury in colon cancer patients: A preliminary analysis

Eiji Oki, Yoshihiro Kakeji, Akinobu Taketomi, Yoichi Yamashita, Kippei Ohgaki, Noboru Harada, Tomohiro Iguchi, Kotaro Shibahara, Noriaki Sadanaga, Masaru Morita, Yoshihiko Maehara

研究成果: ジャーナルへの寄稿記事

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Objective: The prognosis of advanced colon cancer has improved significantly over the last decade since new chemotherapy regimens including oxaliplatin have been developed. However, oxaliplatin-induced liver injury and characterized hepatic hemostatic status can occur after chemotherapy. The assessment of this type of liver injury is often difficult. Methods: Elastography (Fibroscan™) was used to evaluate liver injury in five cases before and after 5-FU, leucovorin, and oxaliplatin combination (FOLFOX) treatment. Results: A clear change was observed in the stiffness of liver after chemotherapy within 48 h, and the hepatic stiffness was normalized in most cases after 2 weeks. Among the five patients, one patient showed aberrant elevation after a FOLFOX treatment, and the patient showed liver injury pathologically. Conclusion: Elastography is a good tool for evaluating hepatic injury after FOLFOX treatment.

元の言語英語
ページ(範囲)82-85
ページ数4
ジャーナルJournal of Gastrointestinal Cancer
39
発行部数1-4
DOI
出版物ステータス出版済み - 3 1 2008

All Science Journal Classification (ASJC) codes

  • Oncology
  • Gastroenterology

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    Oki, E., Kakeji, Y., Taketomi, A., Yamashita, Y., Ohgaki, K., Harada, N., Iguchi, T., Shibahara, K., Sadanaga, N., Morita, M., & Maehara, Y. (2008). Transient Elastography for the prediction of oxaliplatin-associated liver injury in colon cancer patients: A preliminary analysis. Journal of Gastrointestinal Cancer, 39(1-4), 82-85. https://doi.org/10.1007/s12029-009-9063-1