Transient receptor potential channels in Alzheimer's disease

Shinichiro Yamamoto, Teruaki Wajima, Yuji Hara, Motohiro Nishida, Yasuo Mori

研究成果: Contribution to journalReview article査読

83 被引用数 (Scopus)

抄録

Cognitive impairment and emotional disturbances in Alzheimer's disease (AD) result from the degeneration of synapses and neuronal death in the limbic system and associated regions of the cerebral cortex. An alteration in the proteolytic processing of the amyloid precursor protein (APP) results in increased production and accumulation of amyloid β-peptide (Aβ) in the brain. Aβ can render neurons vulnerable to excitotoxicity and apoptosis by disruption of cellular Ca2+ homeostasis and neurotoxic factors including reactive oxygen species (ROS), nitric oxide (NO), and cytokines. Many lines of evidence have suggested that transient receptor potential (TRP) channels consisting of six main subfamilies termed the TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPP (polycystin), TRPML (mucolipin), and TRPA (ankyrin) are involved in Ca2+ homeostasis disruption. Thus, emerging evidence of the pathophysiological role of TRP channels has yielded promising candidates for molecular entities mediating Ca2+ homeostasis disruption in AD. In this review, we focus on the TRP channels in AD and highlight some TRP "suspects" for which a role in AD can be anticipated. An understanding of the involvement of TRP channels in AD may lead to the development of new target therapies.

本文言語英語
ページ(範囲)958-967
ページ数10
ジャーナルBiochimica et Biophysica Acta - Molecular Basis of Disease
1772
8
DOI
出版ステータス出版済み - 8 2007

All Science Journal Classification (ASJC) codes

  • 分子医療
  • 分子生物学

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