Translation initiation from non-AUG codons in cos1 cells is mRNA species dependent

Kailash C. Gupta, Etsuro Ono, Edgardo V. Ariztia, Mutsumi Inaba

研究成果: Contribution to journalArticle査読

8 被引用数 (Scopus)

抄録

Sendai virus P/C mRNA, human erythrocyte membrane protein 4.1 mRNA and PDGF-B chain mRNA were used to test whether translation initiation from non-AUG codons in COS1 cells was mRNA species dependent. Site-directed mutants of the authentic translation start sites of these mRNAs to alternate start codons showed that while P/C mRNA is capable of initiating translation from non-AUG start sites the other two mRNAs are not. Our study shows that translation initiation from non-AUG codons is mRNA species dependent and suggests that higher order structure of an mRNA determines the non-AUG translation start site.

本文言語英語
ページ(範囲)567-573
ページ数7
ジャーナルBiochemical and Biophysical Research Communications
201
2
DOI
出版ステータス出版済み - 6 15 1994
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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