抄録
Ten children were treated with recombinant human tissue plasminogen activator (rh-tPA) for severe hepatic veno-occlusive disease (VOD) that developed after bone marrow transplantation. Treatment with rh-tPA was begun a median of 22 days (range; 13-127 days) after transplantation. Seven of 9 (78%) evaluable patients had complete resolution of their VOD. Four patients had hemorrhagic complications, and 2 of them died because of pulmonary hemorrhage and subdural hemorrhage, respectively. Although rh-tPA seems to be an effective therapy for established VOD, further studies will be necessary to determine its safety as well as the optimal dosing regimen.
本文言語 | 英語 |
---|---|
ページ(範囲) | 103-108 |
ページ数 | 6 |
ジャーナル | [Rinshō ketsueki] The Japanese journal of clinical hematology |
巻 | 41 |
号 | 2 |
出版ステータス | 出版済み - 2月 2000 |
外部発表 | はい |
!!!All Science Journal Classification (ASJC) codes
- 医学(全般)