Treatment of psoriasis with cyclosporine once daily before breakfast (1st report)

Hisashi Kokuba, Futoshi Kohda, Masutaka Furue

研究成果: ジャーナルへの寄稿記事

抜粋

We administered cyclosporine A (NEORAL®) at a daily dose of 2.5 mg/kg before breakfast to seven patients with psoriasis, and measured the drug level at 1 hour after dosing (C1). Relatively rapid improvement of skin manifestations was achieved. Especially in patients with moderate to severe psoriasis and a PASI score of more than twelve points, there was 74.8% improvement of the PASI score at four weeks and 81.6% improvement of the score after eight weeks. As adverse effects, three out of seven patients developed an increase of blood pressure and complained of feeling dull and of flushing. These symptoms were more likely to occur in the patients with relatively high C1 levels (that is more than 1000 ng/ml). In conclusion, administration of NEORAL® once daily before breakfast seems to be a useful method to induce the remission of psoriasis, but further assessment should be done.

元の言語英語
ページ(範囲)665-669
ページ数5
ジャーナルNishinihon Journal of Dermatology
69
発行部数6
DOI
出版物ステータス出版済み - 12 31 2007

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All Science Journal Classification (ASJC) codes

  • Dermatology

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