Treatment planning comparison for carbon ion radiotherapy, proton therapy and intensity-modulated radiotherapy for spinal sarcoma

Keiji Matsumoto, Katsumasa Nakamura, Yoshiyuki Shioyama, Tomonari Sasaki, Ohga Saiji, Toshihiro Yamaguchi, Tadamasa Yoshitake, Kaori Asai, Genyu Kakiuchi, Hiroshi Honda

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

抄録

Background/Aim: Carbon ion radiotherapy (CIRT), proton therapy (PT) and intensity-modulated radiotherapy (IMRT) are new radiation modalities suitable for treatment of spinal sarcomas. The objective of the study was to compare the treatment planning of these modalities. Patients and Methods: We conducted a treatment planning comparison of the three modalities using a phantom imitating a spinal sarcoma and then six actual cases with spinal tumors. A uniform biological effective dose (BED) of 90 Gy10 was prescribed in previously reported fractionation schedules for each modality. The surface/center spinal cord dose constraints were set to BED of 96/77 Gy(E)3, respectively. Results: CIRT achieved better homogeneity of dose distribution and coverage of target than PT independently of tumor extent around the spinal cord. In IMRT plans, the spinal cord dose was higher than that under CIRT and PT and coverage of the target deteriorated depending on the tumor extension. Conclusion: CIRT was most appropriate for the treatment of advanced spinal sarcomas.

元の言語英語
ページ(範囲)4083-4090
ページ数8
ジャーナルAnticancer Research
35
発行部数7
出版物ステータス出版済み - 7 1 2015

Fingerprint

Heavy Ion Radiotherapy
Proton Therapy
Intensity-Modulated Radiotherapy
Sarcoma
Spinal Cord
Therapeutics
Neoplasms
Appointments and Schedules
Radiation

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

Treatment planning comparison for carbon ion radiotherapy, proton therapy and intensity-modulated radiotherapy for spinal sarcoma. / Matsumoto, Keiji; Nakamura, Katsumasa; Shioyama, Yoshiyuki; Sasaki, Tomonari; Saiji, Ohga; Yamaguchi, Toshihiro; Yoshitake, Tadamasa; Asai, Kaori; Kakiuchi, Genyu; Honda, Hiroshi.

:: Anticancer Research, 巻 35, 番号 7, 01.07.2015, p. 4083-4090.

研究成果: ジャーナルへの寄稿記事

@article{5f57c844de3e4d999bebad5ec12ab936,
title = "Treatment planning comparison for carbon ion radiotherapy, proton therapy and intensity-modulated radiotherapy for spinal sarcoma",
abstract = "Background/Aim: Carbon ion radiotherapy (CIRT), proton therapy (PT) and intensity-modulated radiotherapy (IMRT) are new radiation modalities suitable for treatment of spinal sarcomas. The objective of the study was to compare the treatment planning of these modalities. Patients and Methods: We conducted a treatment planning comparison of the three modalities using a phantom imitating a spinal sarcoma and then six actual cases with spinal tumors. A uniform biological effective dose (BED) of 90 Gy10 was prescribed in previously reported fractionation schedules for each modality. The surface/center spinal cord dose constraints were set to BED of 96/77 Gy(E)3, respectively. Results: CIRT achieved better homogeneity of dose distribution and coverage of target than PT independently of tumor extent around the spinal cord. In IMRT plans, the spinal cord dose was higher than that under CIRT and PT and coverage of the target deteriorated depending on the tumor extension. Conclusion: CIRT was most appropriate for the treatment of advanced spinal sarcomas.",
author = "Keiji Matsumoto and Katsumasa Nakamura and Yoshiyuki Shioyama and Tomonari Sasaki and Ohga Saiji and Toshihiro Yamaguchi and Tadamasa Yoshitake and Kaori Asai and Genyu Kakiuchi and Hiroshi Honda",
year = "2015",
month = "7",
day = "1",
language = "English",
volume = "35",
pages = "4083--4090",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "7",

}

TY - JOUR

T1 - Treatment planning comparison for carbon ion radiotherapy, proton therapy and intensity-modulated radiotherapy for spinal sarcoma

AU - Matsumoto, Keiji

AU - Nakamura, Katsumasa

AU - Shioyama, Yoshiyuki

AU - Sasaki, Tomonari

AU - Saiji, Ohga

AU - Yamaguchi, Toshihiro

AU - Yoshitake, Tadamasa

AU - Asai, Kaori

AU - Kakiuchi, Genyu

AU - Honda, Hiroshi

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Background/Aim: Carbon ion radiotherapy (CIRT), proton therapy (PT) and intensity-modulated radiotherapy (IMRT) are new radiation modalities suitable for treatment of spinal sarcomas. The objective of the study was to compare the treatment planning of these modalities. Patients and Methods: We conducted a treatment planning comparison of the three modalities using a phantom imitating a spinal sarcoma and then six actual cases with spinal tumors. A uniform biological effective dose (BED) of 90 Gy10 was prescribed in previously reported fractionation schedules for each modality. The surface/center spinal cord dose constraints were set to BED of 96/77 Gy(E)3, respectively. Results: CIRT achieved better homogeneity of dose distribution and coverage of target than PT independently of tumor extent around the spinal cord. In IMRT plans, the spinal cord dose was higher than that under CIRT and PT and coverage of the target deteriorated depending on the tumor extension. Conclusion: CIRT was most appropriate for the treatment of advanced spinal sarcomas.

AB - Background/Aim: Carbon ion radiotherapy (CIRT), proton therapy (PT) and intensity-modulated radiotherapy (IMRT) are new radiation modalities suitable for treatment of spinal sarcomas. The objective of the study was to compare the treatment planning of these modalities. Patients and Methods: We conducted a treatment planning comparison of the three modalities using a phantom imitating a spinal sarcoma and then six actual cases with spinal tumors. A uniform biological effective dose (BED) of 90 Gy10 was prescribed in previously reported fractionation schedules for each modality. The surface/center spinal cord dose constraints were set to BED of 96/77 Gy(E)3, respectively. Results: CIRT achieved better homogeneity of dose distribution and coverage of target than PT independently of tumor extent around the spinal cord. In IMRT plans, the spinal cord dose was higher than that under CIRT and PT and coverage of the target deteriorated depending on the tumor extension. Conclusion: CIRT was most appropriate for the treatment of advanced spinal sarcomas.

UR - http://www.scopus.com/inward/record.url?scp=84937125405&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84937125405&partnerID=8YFLogxK

M3 - Article

C2 - 26124359

AN - SCOPUS:84937125405

VL - 35

SP - 4083

EP - 4090

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 7

ER -