Tributyltin causes abnormal development in embryos of medaka, Oryzias latipes

Takeshi Hano, Yuji Oshima, Sang Gyoon Kim, Hina Satone, Yumi Oba, Takeshi Kitano, Suguru Inoue, Yohei Shimasaki, Tsuneo Honjo

研究成果: Contribution to journalArticle査読

49 被引用数 (Scopus)

抄録

We examined the effects of tributyltin (TBT) on embryonic development, hatching success and sexual differentiation in Japanese medaka (Oryzias latipes). Embryos (within 8 h after fertilization) were exposed to TBT in ovo via nanoinjection at concentrations of 0 (control), 0.16, 0.80, 3.96, 19.2 and 82.1 ng/egg. Embryonic survival, development and hatching were observed. Hatched fry were reared until 60 days when they sexually matured, and sexual differentiation was also examined by accordance of genetic and phenotypic sex, based on existence of DMY (a male determining gene in medaka) and secondary sex characteristics. As results, TBT caused a concentration-dependent mortality and impaired the embryonic development. However, no masculinization was detected at 60 dph medaka adults. Lowest observed effective concentration for inducing abnormal embryonic development was estimated to 0.16 ng/egg (ca. 160 ng/g egg).

本文言語英語
ページ(範囲)927-933
ページ数7
ジャーナルChemosphere
69
6
DOI
出版ステータス出版済み - 10 2007

All Science Journal Classification (ASJC) codes

  • 環境工学
  • 環境化学
  • 化学 (全般)
  • 汚染
  • 健康、毒物学および変異誘発

フィンガープリント

「Tributyltin causes abnormal development in embryos of medaka, Oryzias latipes」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル