Trifluoroleucine-resistant mutant of Saccharomyces cerevisiae also exhibits pleiotropic drug resistance

Takahiro Oba, Kosuke Tashiro, Satoru Kuhara

研究成果: ジャーナルへの寄稿学術誌査読

抄録

In this study, we revealed that a trifluoroleucine-resistant mutant of Saccharomyces cerevisiae also exhibits pleiotropic drug resistance. DNA microarray analysis of wild-type strain vs. a trifluoroleucine-resistant mutant showed that the PDR5, PDR10, PDR15, and YOR1 genes, encoding the ABC transporter, had high levels of expression. By contrast, the 9 transcriptional factor genes of the ABC transporter, such as PDR1 and PDR3, and the repressor of drug resistance, RDR1, were not up-regulated. When the nucleotide sequences of PDR1 and PDR3 of the wild-type strain and trifluoroleucine-resistant mutant were compared, the sequences of both genes in each strain were identical.

本文言語英語
ページ(範囲)293-296
ページ数4
ジャーナルAnnals of Microbiology
58
2
DOI
出版ステータス出版済み - 1月 1 2008

!!!All Science Journal Classification (ASJC) codes

  • 応用微生物学とバイオテクノロジー

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