Trim36/Haprin plays a critical role in the arrangement of somites during Xenopus embryogenesis

Emi Yoshigai, Shinobu Kawamura, Satoru Kuhara, Kosuke Tashiro

研究成果: ジャーナルへの寄稿学術誌査読

15 被引用数 (Scopus)


The TRIM family members contain a tripartite motif (TRIM), which includes RING, B-box, and coiled-coil domains, or collectively RBCC. They have been implicated in a variety of biological processes, such as the regulation of differentiation and development, and oncogenesis. In this study, we discovered a novel function of the TRIM family in early development. We report the expression of Trim36/Haprin during Xenopus laevis early embryogenesis and its involvement in somite formation. Temporal expression analysis indicated that Trim36/Haprin was present throughout embryogenesis. Spatial expression analysis showed that its expression was mainly confined to the nervous system and a portion of the posterior somite. Morpholino-mediated knockdown of Trim36/Haprin markedly and specifically inhibited the somite formation. We conclude that Trim36/Haprin plays an important role in the arrangement of somites during their formation.

ジャーナルBiochemical and Biophysical Research Communications
出版ステータス出版済み - 1月 16 2009

!!!All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学


「Trim36/Haprin plays a critical role in the arrangement of somites during Xenopus embryogenesis」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。