TRIM8 regulates Nanog via Hsp90β-mediated nuclear translocation of STAT3 in embryonic stem cells

Fumihiko Okumura, Akiko J. Okumura, Masaki Matsumoto, Keiichi I. Nakayama, Shigetsugu Hatakeyama

研究成果: ジャーナルへの寄稿記事

16 引用 (Scopus)

抄録

TRIM8 is a member of a protein family defined by the presence of a common domain structure composed of a tripartite motif including a RING-finger, one or two B-box domains and a coiled-coil motif. Here, we show that TRIM8 interacts with Hsp90β, which interacts with STAT3 and selectively downregulates transcription of Nanog in embryonic stem cells. Knock-down of TRIM8 increased phosphorylated STAT3 in the nucleus and also enhanced transcription of Nanog. These findings suggest that TRIM8 modulates translocation of phosphorylated STAT3 into the nucleus through interaction with Hsp90β and consequently regulates transcription of Nanog in embryonic stem cells.

元の言語英語
ページ(範囲)1784-1792
ページ数9
ジャーナルBiochimica et Biophysica Acta - Molecular Cell Research
1813
発行部数10
DOI
出版物ステータス出版済み - 10 1 2011

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Embryonic Stem Cells
Fingers
Down-Regulation
Proteins

All Science Journal Classification (ASJC) codes

  • Cell Biology
  • Molecular Biology

これを引用

TRIM8 regulates Nanog via Hsp90β-mediated nuclear translocation of STAT3 in embryonic stem cells. / Okumura, Fumihiko; Okumura, Akiko J.; Matsumoto, Masaki; Nakayama, Keiichi I.; Hatakeyama, Shigetsugu.

:: Biochimica et Biophysica Acta - Molecular Cell Research, 巻 1813, 番号 10, 01.10.2011, p. 1784-1792.

研究成果: ジャーナルへの寄稿記事

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