Trimethylamine-N-oxide: Its hydration structure, surface activity, and biological function, viewed by vibrational spectroscopy and molecular dynamics simulations

Tatsuhiko Ohto, Johannes Hunger, Ellen H.G. Backus, Wataru Mizukami, Mischa Bonn, Yuki Nagata

研究成果: Contribution to journalReview article査読

23 被引用数 (Scopus)

抄録

The osmolyte molecule trimethylamine-N-oxide (TMAO) stabilizes the structure of proteins. As functional proteins are generally found in aqueous solutions, an important aspect of this stabilization is the interaction of TMAO with water. Here, we review, using vibrational spectroscopy and molecular dynamics simulations, recent studies on the structure and dynamics of TMAO with its surrounding water molecules. This article ends with an outlook on the open questions on TMAO-protein and TMAO-urea interactions in aqueous environments.

本文言語英語
ページ(範囲)6909-6920
ページ数12
ジャーナルPhysical Chemistry Chemical Physics
19
10
DOI
出版ステータス出版済み - 2017

All Science Journal Classification (ASJC) codes

  • 物理学および天文学(全般)
  • 物理化学および理論化学

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