Tripartite motif-containing 29 (TRIM29) is a novel marker for lymph node metastasis in gastric cancer

Yoshimasa Kosaka, Hiroshi Inoue, Takahiro Ohmachi, Takeshi Yokoe, Toshifumi Matsumoto, Koshi Mimori, Fumiaki Tanaka, Masahiko Watanabe, Masaki Mori

研究成果: ジャーナルへの寄稿記事

70 引用 (Scopus)

抄録

Background: Tripartite motif-containing 29 (TRIM29) belongs to the TRIM protein family, which has unique structural characteristics, including multiple zinc finger motifs and a leucine zipper motif. TRIM29, also known as ataxia telangiectasia group D complementing gene, possesses radiosensitivity suppressor functions. Although TRIM29 has been reported to be underexpressed in prostate and breast cancer, its expression in gastrointestinal cancer has not been studied. Methods: By use of real-time reverse transcriptase-polymerase chain reaction, we analyzed TRIM29 mRNA expression status with respect to various clinicopathological parameters in 124 patients with gastric cancer. An immunohistochemical study was also conducted. Results: The expression of TRIM29 was far higher in gastric cancer tumor tissue. Increased TRIM29 mRNA expression was markedly associated with such parameters as histological grade, large tumor size, extent of tumor invasion, and lymph node metastasis. In the TRIM29 high-expression group, it was an independent predictor for lymph node metastasis. Furthermore, patients with high TRIM29 mRNA expression showed a far poorer survival rate than those with low TRIM29 mRNA expression. Conclusions: TRIM29 expression may serve as a good marker of lymph node metastasis in gastric cancer.

元の言語英語
ページ(範囲)2543-2549
ページ数7
ジャーナルAnnals of Surgical Oncology
14
発行部数9
DOI
出版物ステータス出版済み - 9 1 2007

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Stomach Neoplasms
Lymph Nodes
Neoplasm Metastasis
Messenger RNA
Leucine Zippers
Ataxia Telangiectasia
Neoplasms
Gastrointestinal Neoplasms
Radiation Tolerance
Zinc Fingers
Reverse Transcriptase Polymerase Chain Reaction
Real-Time Polymerase Chain Reaction
Prostatic Neoplasms
Survival Rate
Breast Neoplasms
Genes

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

これを引用

Tripartite motif-containing 29 (TRIM29) is a novel marker for lymph node metastasis in gastric cancer. / Kosaka, Yoshimasa; Inoue, Hiroshi; Ohmachi, Takahiro; Yokoe, Takeshi; Matsumoto, Toshifumi; Mimori, Koshi; Tanaka, Fumiaki; Watanabe, Masahiko; Mori, Masaki.

:: Annals of Surgical Oncology, 巻 14, 番号 9, 01.09.2007, p. 2543-2549.

研究成果: ジャーナルへの寄稿記事

Kosaka, Yoshimasa ; Inoue, Hiroshi ; Ohmachi, Takahiro ; Yokoe, Takeshi ; Matsumoto, Toshifumi ; Mimori, Koshi ; Tanaka, Fumiaki ; Watanabe, Masahiko ; Mori, Masaki. / Tripartite motif-containing 29 (TRIM29) is a novel marker for lymph node metastasis in gastric cancer. :: Annals of Surgical Oncology. 2007 ; 巻 14, 番号 9. pp. 2543-2549.
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title = "Tripartite motif-containing 29 (TRIM29) is a novel marker for lymph node metastasis in gastric cancer",
abstract = "Background: Tripartite motif-containing 29 (TRIM29) belongs to the TRIM protein family, which has unique structural characteristics, including multiple zinc finger motifs and a leucine zipper motif. TRIM29, also known as ataxia telangiectasia group D complementing gene, possesses radiosensitivity suppressor functions. Although TRIM29 has been reported to be underexpressed in prostate and breast cancer, its expression in gastrointestinal cancer has not been studied. Methods: By use of real-time reverse transcriptase-polymerase chain reaction, we analyzed TRIM29 mRNA expression status with respect to various clinicopathological parameters in 124 patients with gastric cancer. An immunohistochemical study was also conducted. Results: The expression of TRIM29 was far higher in gastric cancer tumor tissue. Increased TRIM29 mRNA expression was markedly associated with such parameters as histological grade, large tumor size, extent of tumor invasion, and lymph node metastasis. In the TRIM29 high-expression group, it was an independent predictor for lymph node metastasis. Furthermore, patients with high TRIM29 mRNA expression showed a far poorer survival rate than those with low TRIM29 mRNA expression. Conclusions: TRIM29 expression may serve as a good marker of lymph node metastasis in gastric cancer.",
author = "Yoshimasa Kosaka and Hiroshi Inoue and Takahiro Ohmachi and Takeshi Yokoe and Toshifumi Matsumoto and Koshi Mimori and Fumiaki Tanaka and Masahiko Watanabe and Masaki Mori",
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T1 - Tripartite motif-containing 29 (TRIM29) is a novel marker for lymph node metastasis in gastric cancer

AU - Kosaka, Yoshimasa

AU - Inoue, Hiroshi

AU - Ohmachi, Takahiro

AU - Yokoe, Takeshi

AU - Matsumoto, Toshifumi

AU - Mimori, Koshi

AU - Tanaka, Fumiaki

AU - Watanabe, Masahiko

AU - Mori, Masaki

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Y1 - 2007/9/1

N2 - Background: Tripartite motif-containing 29 (TRIM29) belongs to the TRIM protein family, which has unique structural characteristics, including multiple zinc finger motifs and a leucine zipper motif. TRIM29, also known as ataxia telangiectasia group D complementing gene, possesses radiosensitivity suppressor functions. Although TRIM29 has been reported to be underexpressed in prostate and breast cancer, its expression in gastrointestinal cancer has not been studied. Methods: By use of real-time reverse transcriptase-polymerase chain reaction, we analyzed TRIM29 mRNA expression status with respect to various clinicopathological parameters in 124 patients with gastric cancer. An immunohistochemical study was also conducted. Results: The expression of TRIM29 was far higher in gastric cancer tumor tissue. Increased TRIM29 mRNA expression was markedly associated with such parameters as histological grade, large tumor size, extent of tumor invasion, and lymph node metastasis. In the TRIM29 high-expression group, it was an independent predictor for lymph node metastasis. Furthermore, patients with high TRIM29 mRNA expression showed a far poorer survival rate than those with low TRIM29 mRNA expression. Conclusions: TRIM29 expression may serve as a good marker of lymph node metastasis in gastric cancer.

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