TY - JOUR
T1 - Triterpenoid saponins from Polycarpaea corymbosa Lamk. var. eriantha Hochst
AU - Manase, Mahenina Jaovita
AU - Mitaine-Offer, Anne Claire
AU - Miyamoto, Tomofumi
AU - Tanaka, Chiaki
AU - Delemasure, Stéphanie
AU - Dutartre, Patrick
AU - Lacaille-Dubois, Marie Aleth
PY - 2014/4/1
Y1 - 2014/4/1
N2 - Four triterpenoid saponins (1-4) were isolated from Polycarpaea corymbosa Lamk. var. eriantha Hochst along with the known apoanagallosaponin IV (5). Their structures were elucidated by spectroscopic data analysis. Among the compounds 1, 3-5 which were evaluated for their cytotoxicity against three tumor cell lines (SW480, DU145 and EMT6), compound 1 exhibited cytotoxicity with IC 50 values ranging from 4.61 to 22.61 μM, which was greater than that of etoposide. Compound 2 was tested only against SW480 and a cardiomyoblast cell line (H9c2), and was inactive.
AB - Four triterpenoid saponins (1-4) were isolated from Polycarpaea corymbosa Lamk. var. eriantha Hochst along with the known apoanagallosaponin IV (5). Their structures were elucidated by spectroscopic data analysis. Among the compounds 1, 3-5 which were evaluated for their cytotoxicity against three tumor cell lines (SW480, DU145 and EMT6), compound 1 exhibited cytotoxicity with IC 50 values ranging from 4.61 to 22.61 μM, which was greater than that of etoposide. Compound 2 was tested only against SW480 and a cardiomyoblast cell line (H9c2), and was inactive.
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U2 - 10.1016/j.phytochem.2013.12.005
DO - 10.1016/j.phytochem.2013.12.005
M3 - Article
C2 - 24507482
AN - SCOPUS:84897640365
VL - 100
SP - 150
EP - 155
JO - Phytochemistry
JF - Phytochemistry
SN - 0031-9422
ER -