The effects of acidic pH were examined on the Ca2+-sensitive ATPase activity of chicken fast and slow skeletal muscle myofibrils. In both types of myofibrils the Ca2+-sensitivity declined on decreasing pH from 7.4 to 6.2, but the slow skeletal muscle myofibrils were found to exhibit a Ca2+-sensitive ATPase activity which was more resistant to acidic pH compared to the fast skeletal muscle myofibrils. The results obtained by using a novel method for replacing whole troponin complex in myofibrils provide the first evidence that troponin is responsible for this higher resistibility of slow skeletal muscle myofibrils to acidosis.
|ジャーナル||Biochemical and Biophysical Research Communications|
|出版ステータス||出版済み - 1 1 1995|
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cell Biology