Tumor-derived tenascin-C promotes the epithelial-mesenchymal transition in colorectal cancer cells

Yusuke Takahashi, Genta Sawada, Junji Kurashige, Tae Matsumura, Ryutaro Uchi, Hiroki Ueo, Masahisa Ishibashi, Yuki Takano, Sayuri Akiyoshi, Takeshi Iwaya, Hidetoshi Eguchi, Tomoya Sudo, Keishi Sugimachi, Hirofumi Yamamoto, Yuichiro Doki, Masaki Mori, Koshi Mimori

研究成果: ジャーナルへの寄稿記事

16 引用 (Scopus)


Background: Tenascin-C (TNC) is an extracellular matrix glycoprotein, usually derived from myofibroblasts in the cancer microenvironment. Recently, however, the significance of tumor-derived TNC in initiation of cancer metastasis was disclosed. We investigated the clinical significance of cancer-derived TNC in colorectal cancer (CRC) cases. Materials and Methods: TNC expression in 170 cases of CRC was analyzed by quantitative real-time polymerase chain reaction (PCR). In addition, gene expression arrays using purely-separated cancer tissues of another 86 cases was performed and the functional implications of cancer-specific TNC were investigated. Results: The expression of TNC mRNA was significantly higher in CRC tissues than in the corresponding normal tissues. Cancer cell-specific TNC expression was a significant prognostic factor in CRC cases. Moreover, cancer cell-derived TNC was associated with the epithelial-mesenchymal transition (EMT) signature. Conclusion: Cancer cell-derived TNC promotes cancer invasiveness via EMT regulation, and not cancer tissue TNC but cancer cell-specific TNC is a novel indicator of poor prognosis.

ジャーナルAnticancer research
出版物ステータス出版済み - 5 1 2013


All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


Takahashi, Y., Sawada, G., Kurashige, J., Matsumura, T., Uchi, R., Ueo, H., ... Mimori, K. (2013). Tumor-derived tenascin-C promotes the epithelial-mesenchymal transition in colorectal cancer cells. Anticancer research, 33(5), 1927-1934.