Tumor necrosis factor and fever at diagnosis in children with solid tumors

Eiichi Ishii, Shouichi Ohga, Kohji Ueda

研究成果: Contribution to journalArticle査読

5 被引用数 (Scopus)

抄録

In order to determine the pathogenesis of fever in solid tumors, we studied the association of fever at diagnosis in children with solid tumors (malignant lymphoma, rhabdomyosarcoma, and neuroblastoma), serum levels of interleukin 1 (IL-1), and tumor necrosis factor. Thirteen of 20 patients (65% with solid tumors were complicated with fever at diagnosis. There was no difference in C-reactive protein or IL-1 levels between the patients with and without fever, while the erythrocyte sedimentation rate and TNF levels were higher in the former than in the latter by Wilcoxon's rank sum test (p < 0.01). These findings suggest that most febrile episodes at diagnosis in children with solid tumors are associated with the release of tumor necrosis factor.

本文言語英語
ページ(範囲)253-257
ページ数5
ジャーナルPediatric Hematology and Oncology
7
3
DOI
出版ステータス出版済み - 1 1 1990

All Science Journal Classification (ASJC) codes

  • 小児科学、周産期医学および子どもの健康
  • 血液学
  • 腫瘍学

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