Two case reports of intra-articular nodular fasciitis of the knee confirmed by MYH9-USP6 gene fusion expression

Akira Miyama, Shigeyuki Kuratsu, Satoshi Takenaka, Michiko Yoshimura, Genichiro Yoneda, Yuichi Yamada, Yoshinao Oda

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

抄録

Aim: To describe two cases of intra-articular nodular fasciitis (NF) which developed within the knee joint and were associated with the expression of the MYH9-USP6 gene fusion. Patients and methods: Two women, 30 and 56 years of age, with no history of joint disease or knee joint trauma, are presented in our cases. We report these cases describing the clinical presentation, assessment, histopathological examination, gene expression, and clinical management. Results: Both patients presented with knee pain and limitation in the range of flexion. We diagnosed our two cases as intraarticular nodular fasciitis based on histological findings and by the detection of the MYH9-USP6 gene fusion. The transcript of MYH9-USP6 gene fusion was identified by RT-PCR and direct sequencing in both cases. Conclusion: We report the first cases of intra-articular NF involving the knee joint, with identification of a MYH9-USP6 gene fusion by RT-PCR. NF should be considered in the differential diagnosis of intra-articular lesions.

元の言語英語
ジャーナルJournal of Orthopaedic Science
DOI
出版物ステータス受理済み/印刷中 - 1 1 2019

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Fasciitis
Gene Fusion
Knee
Knee Joint
Joints
Gene Expression
Polymerase Chain Reaction
Joint Diseases
Differential Diagnosis
Pain
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Surgery
  • Orthopedics and Sports Medicine

これを引用

Two case reports of intra-articular nodular fasciitis of the knee confirmed by MYH9-USP6 gene fusion expression. / Miyama, Akira; Kuratsu, Shigeyuki; Takenaka, Satoshi; Yoshimura, Michiko; Yoneda, Genichiro; Yamada, Yuichi; Oda, Yoshinao.

:: Journal of Orthopaedic Science, 01.01.2019.

研究成果: ジャーナルへの寄稿記事

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abstract = "Aim: To describe two cases of intra-articular nodular fasciitis (NF) which developed within the knee joint and were associated with the expression of the MYH9-USP6 gene fusion. Patients and methods: Two women, 30 and 56 years of age, with no history of joint disease or knee joint trauma, are presented in our cases. We report these cases describing the clinical presentation, assessment, histopathological examination, gene expression, and clinical management. Results: Both patients presented with knee pain and limitation in the range of flexion. We diagnosed our two cases as intraarticular nodular fasciitis based on histological findings and by the detection of the MYH9-USP6 gene fusion. The transcript of MYH9-USP6 gene fusion was identified by RT-PCR and direct sequencing in both cases. Conclusion: We report the first cases of intra-articular NF involving the knee joint, with identification of a MYH9-USP6 gene fusion by RT-PCR. NF should be considered in the differential diagnosis of intra-articular lesions.",
author = "Akira Miyama and Shigeyuki Kuratsu and Satoshi Takenaka and Michiko Yoshimura and Genichiro Yoneda and Yuichi Yamada and Yoshinao Oda",
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AU - Miyama, Akira

AU - Kuratsu, Shigeyuki

AU - Takenaka, Satoshi

AU - Yoshimura, Michiko

AU - Yoneda, Genichiro

AU - Yamada, Yuichi

AU - Oda, Yoshinao

PY - 2019/1/1

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N2 - Aim: To describe two cases of intra-articular nodular fasciitis (NF) which developed within the knee joint and were associated with the expression of the MYH9-USP6 gene fusion. Patients and methods: Two women, 30 and 56 years of age, with no history of joint disease or knee joint trauma, are presented in our cases. We report these cases describing the clinical presentation, assessment, histopathological examination, gene expression, and clinical management. Results: Both patients presented with knee pain and limitation in the range of flexion. We diagnosed our two cases as intraarticular nodular fasciitis based on histological findings and by the detection of the MYH9-USP6 gene fusion. The transcript of MYH9-USP6 gene fusion was identified by RT-PCR and direct sequencing in both cases. Conclusion: We report the first cases of intra-articular NF involving the knee joint, with identification of a MYH9-USP6 gene fusion by RT-PCR. NF should be considered in the differential diagnosis of intra-articular lesions.

AB - Aim: To describe two cases of intra-articular nodular fasciitis (NF) which developed within the knee joint and were associated with the expression of the MYH9-USP6 gene fusion. Patients and methods: Two women, 30 and 56 years of age, with no history of joint disease or knee joint trauma, are presented in our cases. We report these cases describing the clinical presentation, assessment, histopathological examination, gene expression, and clinical management. Results: Both patients presented with knee pain and limitation in the range of flexion. We diagnosed our two cases as intraarticular nodular fasciitis based on histological findings and by the detection of the MYH9-USP6 gene fusion. The transcript of MYH9-USP6 gene fusion was identified by RT-PCR and direct sequencing in both cases. Conclusion: We report the first cases of intra-articular NF involving the knee joint, with identification of a MYH9-USP6 gene fusion by RT-PCR. NF should be considered in the differential diagnosis of intra-articular lesions.

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