Two cases of myocardial infarction in type 4 Ehlers-Danlos syndrome

T. Kitazono, T. Imaizumi, S. Imayama, H. Shinkai, A. Takeshita, M. Nakamura

研究成果: Contribution to journalArticle査読

15 被引用数 (Scopus)


Ehlers-Danlos syndrome is an inherited connective tissue disorder. Clinical manifestations of this syndrome are due to fragile connective tissue. Though many cardiovascular disorders in association with it have been reported, myocardial infarction is quite rare. In this report, two cases with type 4 Ehlers-Danlos syndrome and myocardial infarction are described. Patient 1 was a 30-year-old woman. She was diagnosed as having myocardial infarction on the basis of typical changes in electrocardiograms and serum enzymes (CPK, SGOT and LDH). The diagnosis of type 4 Ehlers-Danlos syndrome was made by the microscopic examination of her connective tissue. Patient 2 was a 32-year-old man. He was also diagnosed as having acute myocardial infarction. His fibroblasts were cultured and they could not synthesize type 3 collagen. Type 4 Ehlers-Danlos syndrome was diagnosed. It was likely that myocardial infarction might have resulted from the fragility of their coronary arteries in type 4 Ehlers-Danlos syndrome.

出版ステータス出版済み - 1989

All Science Journal Classification (ASJC) codes

  • 呼吸器内科
  • 集中医療医学
  • 循環器および心血管医学


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