Two cases of systemic amyloidosis with deposition of amyloid protein in the skin

Midori Tsutsumi, Chikage Mitoma, Takamichi Ito, Yumiko Kaku, Saori Ito, Makiko Kido-Nakahara, Masutaka Furue

研究成果: ジャーナルへの寄稿記事

抄録

We report two cases of systemic amyloidosis with deposition of amyloid protein in the skin. Case 1) A 49-year-old man complained of nausea seven months before the first medical examination. Subsequently, he had severe orthostatic hypotension and chronic diarrhea, resulting in 23 kg weight loss in a half year. Heart failure and polyneuropathy also gradually developed. Endoscopic biopsy revealed amyloid deposition in stomach, duodenum, ileum, cecum, and colon. He was diagnosed as lymphoplasmacytic lymphoma by bone marrow puncture. He was referred to our department for the diagnosis of 3-5 mm sized red papules scattered on his shoulder and back. Histologically, amyloid deposits immunoreactive to immunoglobulin light chain were confirmed in the papillary dermis, together with the perineural and perivascular areas of the subcutis, leading to the diagnosis of immunocytic amyloidosis. Case 2) A 77-year-old woman with rheumatoid arthritis for 37 years suffered from renal insufficiency due to secondary amyloidosis 21 years after the diagnosis of rheumatoid arthritis; thereafter, hemodialysis treatment was initiated at the age of 73 years. She developed pruritic erythema on her chest. On histology, amyloid A and β2-microglobulin-positive deposits were evident around sweat glands. We diagnosed the patient as reactive AA amyloidosis induced by rheumatoid arthritis associated with dialysis amyloidosis. In the present two cases, the amyloid deposits were found in both lesional and non-lesional skin, suggesting a usefulness of skin biopsy in the diagnosis of systemic amyloidosis.

元の言語英語
ページ(範囲)364-369
ページ数6
ジャーナルNishinihon Journal of Dermatology
77
発行部数4
DOI
出版物ステータス出版済み - 1 1 2015

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Amyloidogenic Proteins
Amyloidosis
Skin
Rheumatoid Arthritis
Amyloid Plaques
Amyloid
Immunoglobulin Light Chains
Biopsy
Sweat Glands
Orthostatic Hypotension
Cecum
Polyneuropathies
Erythema
Dermis
Ileum
Duodenum
Punctures
Nausea
Renal Insufficiency
Renal Dialysis

All Science Journal Classification (ASJC) codes

  • Dermatology

これを引用

Two cases of systemic amyloidosis with deposition of amyloid protein in the skin. / Tsutsumi, Midori; Mitoma, Chikage; Ito, Takamichi; Kaku, Yumiko; Ito, Saori; Kido-Nakahara, Makiko; Furue, Masutaka.

:: Nishinihon Journal of Dermatology, 巻 77, 番号 4, 01.01.2015, p. 364-369.

研究成果: ジャーナルへの寄稿記事

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