Two-component signal transduction as potential drug targets in pathogenic bacteria

Yasuhiro Gotoh, Yoko Eguchi, Takafumi Watanabe, Sho Okamoto, Akihiro Doi, Ryutaro Utsumi

研究成果: ジャーナルへの寄稿評論記事

166 引用 (Scopus)

抄録

Gene clusters contributing to processes such as cell growth and pathogenicity are often controlled by two-component signal transduction systems (TCSs). Specific inhibitors against TCS systems work differently from conventional antibiotics, and developing them into new drugs that are effective against various drug-resistant bacteria may be possible. Furthermore, inhibitors of TCSs that control virulence factors may reduce virulence without killing the pathogenic bacteria. Previous TCS inhibitors targeting the kinase domain of the histidine kinase sensor suffered from poor selectivity. Recent TCS inhibitors, however, target the sensory domains of the sensors blocking the quorum sensing system, or target the essential response regulator. These new targets are introduced, together with several specific TCSs that have the potential to serve as effective drug targets.

元の言語英語
ページ(範囲)232-239
ページ数8
ジャーナルCurrent Opinion in Microbiology
13
発行部数2
DOI
出版物ステータス出版済み - 4 1 2010
外部発表Yes

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Signal Transduction
Bacteria
Virulence
Pharmaceutical Preparations
Quorum Sensing
Virulence Factors
Multigene Family
Phosphotransferases
Anti-Bacterial Agents
Growth
Histidine Kinase

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases

これを引用

Two-component signal transduction as potential drug targets in pathogenic bacteria. / Gotoh, Yasuhiro; Eguchi, Yoko; Watanabe, Takafumi; Okamoto, Sho; Doi, Akihiro; Utsumi, Ryutaro.

:: Current Opinion in Microbiology, 巻 13, 番号 2, 01.04.2010, p. 232-239.

研究成果: ジャーナルへの寄稿評論記事

Gotoh, Yasuhiro ; Eguchi, Yoko ; Watanabe, Takafumi ; Okamoto, Sho ; Doi, Akihiro ; Utsumi, Ryutaro. / Two-component signal transduction as potential drug targets in pathogenic bacteria. :: Current Opinion in Microbiology. 2010 ; 巻 13, 番号 2. pp. 232-239.
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