Two major genes, linked to HLA and Gm, control susceptibility to Graves' disease

Hisamitsu Uno, Takehiko Sasazuki, Hajime Tamai, Hideo Matsumoto

研究成果: Contribution to journalArticle査読

158 被引用数 (Scopus)

抄録

Graves' disease is a multifactorial disease in which immunogenetic as well as environmental factors have important roles. Recently, cumulative evidence has shown that genes controlling immune responses are linked to the MHC (major histocompatibility complex)1 and/or immunoglobulin allotype genes2,3. To identify the genes governing susceptibility to Graves' disease, we have studied 30 Japanese families where more than two first degree relatives were affected with the disease. From genetic analysis of HLA (human MHC) and immunoglobulin allotype of all family members, we present here evidence for the existence of two genes controlling the susceptibility to Graves' disease, one closely linked to HLA-DR, the other linked to the gene coding for the Gm allotype.

本文言語英語
ページ(範囲)768-770
ページ数3
ジャーナルNature
292
5825
DOI
出版ステータス出版済み - 1981
外部発表はい

All Science Journal Classification (ASJC) codes

  • 一般

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