Two new polyhydroxylated steroids from Egyptian soft coral Heteroxenia fuscescens (Fam.; Xeniidae)

Fahd M. Abdelkarem, Ezz Eldin K. Desoky, Alaa M. Nafady, Ahmed E. Allam, Aldoushy Mahdy, Ahmed Ashour, Gamal A. Mohamed, Tomofumi Miyamoto, Kuniyoshi Shimizu

研究成果: ジャーナルへの寄稿記事

抄録

Two new polyhydroxylated steroids, 3β-acetoxy-gorgost-5α,6β,11α-triol (3) and (23 R) methylergosta-20-ene-3β,5α,6β,17α-tetrol (4), together with three known gorgosteroid compounds, gorgost-3β, 5α,6β,11α- tetrol (1), 11α-acetoxy-gorgost- 3β,5α, 6β- triol (2), and gorgost-5 (E) ene-3-β-ol (5), as well as batyl alcohol (6), were isolated from the Egyptian soft coral Heteroxenia fuscescens. The structures of these compounds were elucidated based on NMR spectroscopic analyses, HR-FAB-MS, and comparisons with published data. The cytotoxic activities of the fractions and compounds were evaluated against MCF-7 cancer cell lines using MTT colorimetric assay. Compounds 2 and 4 showed moderate cytotoxic activity, with IC50 values equal to 33.2 and 25.1 µM, respectively, in comparison with the IC50 of 5-fluorouracil 18.7 µM.

元の言語英語
ジャーナルNatural Product Research
DOI
出版物ステータス出版済み - 1 1 2019

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Anthozoa
Fluorouracil
Inhibitory Concentration 50
steroids
inhibitory concentration 50
corals
Assays
Steroids
Cells
Nuclear magnetic resonance
fluorouracil
MCF-7 Cells
alcohols
cell lines
Cell Line
assays
Neoplasms
batyl alcohol
neoplasm cells

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

これを引用

Two new polyhydroxylated steroids from Egyptian soft coral Heteroxenia fuscescens (Fam.; Xeniidae). / Abdelkarem, Fahd M.; Desoky, Ezz Eldin K.; Nafady, Alaa M.; Allam, Ahmed E.; Mahdy, Aldoushy; Ashour, Ahmed; Mohamed, Gamal A.; Miyamoto, Tomofumi; Shimizu, Kuniyoshi.

:: Natural Product Research, 01.01.2019.

研究成果: ジャーナルへの寄稿記事

Abdelkarem, Fahd M. ; Desoky, Ezz Eldin K. ; Nafady, Alaa M. ; Allam, Ahmed E. ; Mahdy, Aldoushy ; Ashour, Ahmed ; Mohamed, Gamal A. ; Miyamoto, Tomofumi ; Shimizu, Kuniyoshi. / Two new polyhydroxylated steroids from Egyptian soft coral Heteroxenia fuscescens (Fam.; Xeniidae). :: Natural Product Research. 2019.
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abstract = "Two new polyhydroxylated steroids, 3β-acetoxy-gorgost-5α,6β,11α-triol (3) and (23 R) methylergosta-20-ene-3β,5α,6β,17α-tetrol (4), together with three known gorgosteroid compounds, gorgost-3β, 5α,6β,11α- tetrol (1), 11α-acetoxy-gorgost- 3β,5α, 6β- triol (2), and gorgost-5 (E) ene-3-β-ol (5), as well as batyl alcohol (6), were isolated from the Egyptian soft coral Heteroxenia fuscescens. The structures of these compounds were elucidated based on NMR spectroscopic analyses, HR-FAB-MS, and comparisons with published data. The cytotoxic activities of the fractions and compounds were evaluated against MCF-7 cancer cell lines using MTT colorimetric assay. Compounds 2 and 4 showed moderate cytotoxic activity, with IC50 values equal to 33.2 and 25.1 µM, respectively, in comparison with the IC50 of 5-fluorouracil 18.7 µM.",
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AU - Nafady, Alaa M.

AU - Allam, Ahmed E.

AU - Mahdy, Aldoushy

AU - Ashour, Ahmed

AU - Mohamed, Gamal A.

AU - Miyamoto, Tomofumi

AU - Shimizu, Kuniyoshi

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