TY - JOUR
T1 - Two new polyhydroxylated steroids from Egyptian soft coral Heteroxenia fuscescens (Fam.; Xeniidae)
AU - Abdelkarem, Fahd M.
AU - Desoky, Ezz Eldin K.
AU - Nafady, Alaa M.
AU - Allam, Ahmed E.
AU - Mahdy, Aldoushy
AU - Ashour, Ahmed
AU - Mohamed, Gamal A.
AU - Miyamoto, Tomofumi
AU - Shimizu, Kuniyoshi
N1 - Funding Information:
We would like to express our praise to Dr. Shingo Yokota, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Japan, for carrying out the IR measurements. F. M. A. gratefully acknowledges the cultural affairs section and the Ministry of Higher Education, Egypt for scholarship support.
Publisher Copyright:
© 2019 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2021
Y1 - 2021
N2 - Two new polyhydroxylated steroids, 3β-acetoxy-gorgost-5α,6β,11α-triol (3) and (23 R) methylergosta-20-ene-3β,5α,6β,17α-tetrol (4), together with three known gorgosteroid compounds, gorgost-3β, 5α,6β,11α- tetrol (1), 11α-acetoxy-gorgost- 3β,5α, 6β- triol (2), and gorgost-5 (E) ene-3-β-ol (5), as well as batyl alcohol (6), were isolated from the Egyptian soft coral Heteroxenia fuscescens. The structures of these compounds were elucidated based on NMR spectroscopic analyses, HR-FAB-MS, and comparisons with published data. The cytotoxic activities of the fractions and compounds were evaluated against MCF-7 cancer cell lines using MTT colorimetric assay. Compounds 2 and 4 showed moderate cytotoxic activity, with IC50 values equal to 33.2 and 25.1 µM, respectively, in comparison with the IC50 of 5-fluorouracil 18.7 µM.
AB - Two new polyhydroxylated steroids, 3β-acetoxy-gorgost-5α,6β,11α-triol (3) and (23 R) methylergosta-20-ene-3β,5α,6β,17α-tetrol (4), together with three known gorgosteroid compounds, gorgost-3β, 5α,6β,11α- tetrol (1), 11α-acetoxy-gorgost- 3β,5α, 6β- triol (2), and gorgost-5 (E) ene-3-β-ol (5), as well as batyl alcohol (6), were isolated from the Egyptian soft coral Heteroxenia fuscescens. The structures of these compounds were elucidated based on NMR spectroscopic analyses, HR-FAB-MS, and comparisons with published data. The cytotoxic activities of the fractions and compounds were evaluated against MCF-7 cancer cell lines using MTT colorimetric assay. Compounds 2 and 4 showed moderate cytotoxic activity, with IC50 values equal to 33.2 and 25.1 µM, respectively, in comparison with the IC50 of 5-fluorouracil 18.7 µM.
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U2 - 10.1080/14786419.2019.1624958
DO - 10.1080/14786419.2019.1624958
M3 - Article
C2 - 31170807
AN - SCOPUS:85067573443
SN - 1478-6419
VL - 35
SP - 236
EP - 243
JO - Natural Product Research
JF - Natural Product Research
IS - 2
ER -
