Two new triterpenoid saponins: telephiifoliosides A and B from the roots of Corrigiola litoralis subsp. telephiifolia (Pourr.) Briq

Romuald Tématio Fouedjou, Beaudelaire Kemvoufo Ponou, Rémy Bertrand Teponno, Matthias Melzig, Chiaki Tanaka, Tomofumi Miyamoto, Léon Azefack Tapondjou

研究成果: Contribution to journalArticle査読

抄録

The polar fraction of the MeOH extract of the roots of Corrigiola litoralis subsp. telephiifolia (Pourr.) Briq. (Caryophyllaceae) was investigated for its constituents and two previously unreported monodesmosides triterpene saponins, telephiifoliosides A and B (1 and 2), along with the known bonushenricoside A (3) were isolated. Their structures were elucidated by combined spectroscopic and spectrometric techniques (1H NMR, 13C NMR, HSQC, 1H-1H COSY, HMBC, TOCSY, NOESY, HRESIMS) and chemical methods. The structures of the new saponins were established as; 3-O-α-L-arabinopyranosyljaligonic acid (1), and 3-O-α-L-arabinopyranosylphytolaccagenin ester (2). Upon evaluation of the antiproliferative activity on human malignant epithelial (HeLa) cells, none of the isolated compounds was efficient at the concentration of 33 µM. Highlights This is the first phytochemical study on Corrigiola litoralis subsp. telephiifolia. Two new saponins were isolated from the roots of Corrigiola litoralis subsp. telephiifolia. The isolated compounds were tested for their antiproliferative activity.

本文言語英語
ジャーナルNatural Product Research
DOI
出版ステータス受理済み/印刷中 - 2021

All Science Journal Classification (ASJC) codes

  • 分析化学
  • 生化学
  • 植物科学
  • 有機化学

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