Two polymorphisms within interleukin-3 (hlL3) gene detected by mismatch PCR/RFLP

H. Nakashima, T. Otsuka, Y. Ohba, M. Akahoshi, S. Nagano, E. Ogami, Y. Arinobu, K. Miyake, Y. Inoue, H. Niiro, Y. Kaji, Y. Niho

研究成果: Contribution to journalArticle査読

2 被引用数 (Scopus)

抄録

Two alleles of IL-3 have been reported to GenBank (GenBank M14743, M20137). The sequence difference between these two alleles is at the first nucleotide of the 27th codon (the 131st nucleotide from the initiation site): thymine and cytosine, and leading the amino acid difference: proline and serine (Pro27Ser). The other allelism, thymine and cytosine, was also observed at position -16 of the IL-3 upstream promotor region (GenBank L10616, M60870). We clarified that these substitutions were frequent polymorphisms in the Japanese population by using the mismatch-PCR (polymerase chain reaction)/RFLP (restriction fragment length polymorphism) method.

本文言語英語
ページ(範囲)156-158
ページ数3
ジャーナルGenes and Immunity
1
2
DOI
出版ステータス出版済み - 11 1999

All Science Journal Classification (ASJC) codes

  • Immunology
  • Genetics
  • Genetics(clinical)

フィンガープリント 「Two polymorphisms within interleukin-3 (hlL3) gene detected by mismatch PCR/RFLP」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル