Two types of interleukin 17A-producing γδ T cells in protection against pulmonary infection with klebsiella pneumoniae

Tesshin Murakami, Shinya Hatano, Hisakata Yamada, Yoichiro Iwakura, Yasunobu Yoshikai

研究成果: Contribution to journalArticle査読

18 被引用数 (Scopus)

抄録

Background. Klebsiella pneumoniae frequently causes life-threatening infection in children. Interleukin 17A (IL-17A) is known to be involved in protection against K. pneumoniae infection through activation of neutrophils. Methods and Results. We found that IL-17A-producing γδ T cells existed more frequently in younger mice on examination of IL-17A-producing lymphocytes in the lung of naive mice at various ages. We hence compared the protective role of IL-17A-producing γδ T cells against pulmonary K. pneumoniae infection in young (3 weeks old) and adult (8-12 weeks old) mice. IL-17A-deficient mice were susceptible to K. pneumonia regardless of age. Cγ-, Vγ4/6-, or Vd1-deficient mice were susceptible to K. pneumonia at young age, while interleukin 23p19 (IL-23p19)-deficient mice were susceptible at adult age. IL-17A-producing Vγ1-Vγ4-γδ T cells expressing canonical Vγ6/Vd1 genes were dominant over IL-17A-producing Vγ4+ γδ T cells in the lungs of young mice after infection. The IL-17A-producing Vγ1-Vγ4-γδ T cells expressed an activation marker, CD69, and proliferated in an IL-23-independent manner, while the IL-17A-producing Vγ4+ γδ T cells expressing IL-23 receptor but no CD69 proliferated in IL-23-dependent manner. Conclusions. These results suggest that 2 types of IL-17A-producing γδ T cells are activated for host defense against K. pneumoniae infection by IL-23-dependent or independent mechanism.

本文言語英語
ページ(範囲)1752-1761
ページ数10
ジャーナルJournal of Infectious Diseases
214
11
DOI
出版ステータス出版済み - 12 1 2016

All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • 感染症

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