Tyk2 plays a restricted role in IFNα signaling, although it is required for IL-12-mediated T cell function

Kazuya Shimoda, Kouji Kato, Kenichi Aoki, Tadashi Matsuda, Akitomo Miyamoto, Masafumi Shibamori, Masakatsu Yamashita, Akihiko Numata, Ken Takase, Shinji Kobayashi, Shouichirou Shibata, Yoshinobu Asano, Hisashi Gondo, Kazuo Sekiguchi, Keiko Nakayama, Toshinori Nakayama, Takashi Okamura, Seiichi Okamura, Yoshiyuki Niho, Kei ichi Nakayama

研究成果: ジャーナルへの寄稿記事

234 引用 (Scopus)

抄録

Janus kinases (Jaks) play an important role in signal transduction via cytokine receptors. Tyk2 is a Janus kinase, and we developed tyk2-deficient mice to study the requirement for tyk2 in vivo. Tyk2-deficient mice show no overt developmental abnormalities; however, they display a lack of responsiveness to a small amount of IFNα, although a high concentration of IFNα can fully transduce its signal even in the absence of tyk2. Furthermore, IL-12-induced T cell function is defective in these mice. In contrast, these mice respond normally to IL-6 and IL-10, both of which activate tyk2 in vitro. These observations demonstrate that tyk2 plays only a restricted role in mediating IFNα-dependent signaling while being required in mediating IL-12-dependent biological responses.

元の言語英語
ページ(範囲)561-571
ページ数11
ジャーナルImmunity
13
発行部数4
DOI
出版物ステータス出版済み - 1 1 2000

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Interleukin-12
Janus Kinases
T-Lymphocytes
Cytokine Receptors
Interleukin-10
Interleukin-6
Signal Transduction

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

これを引用

Tyk2 plays a restricted role in IFNα signaling, although it is required for IL-12-mediated T cell function. / Shimoda, Kazuya; Kato, Kouji; Aoki, Kenichi; Matsuda, Tadashi; Miyamoto, Akitomo; Shibamori, Masafumi; Yamashita, Masakatsu; Numata, Akihiko; Takase, Ken; Kobayashi, Shinji; Shibata, Shouichirou; Asano, Yoshinobu; Gondo, Hisashi; Sekiguchi, Kazuo; Nakayama, Keiko; Nakayama, Toshinori; Okamura, Takashi; Okamura, Seiichi; Niho, Yoshiyuki; Nakayama, Kei ichi.

:: Immunity, 巻 13, 番号 4, 01.01.2000, p. 561-571.

研究成果: ジャーナルへの寄稿記事

Shimoda, K, Kato, K, Aoki, K, Matsuda, T, Miyamoto, A, Shibamori, M, Yamashita, M, Numata, A, Takase, K, Kobayashi, S, Shibata, S, Asano, Y, Gondo, H, Sekiguchi, K, Nakayama, K, Nakayama, T, Okamura, T, Okamura, S, Niho, Y & Nakayama, KI 2000, 'Tyk2 plays a restricted role in IFNα signaling, although it is required for IL-12-mediated T cell function', Immunity, 巻. 13, 番号 4, pp. 561-571. https://doi.org/10.1016/S1074-7613(00)00055-8
Shimoda, Kazuya ; Kato, Kouji ; Aoki, Kenichi ; Matsuda, Tadashi ; Miyamoto, Akitomo ; Shibamori, Masafumi ; Yamashita, Masakatsu ; Numata, Akihiko ; Takase, Ken ; Kobayashi, Shinji ; Shibata, Shouichirou ; Asano, Yoshinobu ; Gondo, Hisashi ; Sekiguchi, Kazuo ; Nakayama, Keiko ; Nakayama, Toshinori ; Okamura, Takashi ; Okamura, Seiichi ; Niho, Yoshiyuki ; Nakayama, Kei ichi. / Tyk2 plays a restricted role in IFNα signaling, although it is required for IL-12-mediated T cell function. :: Immunity. 2000 ; 巻 13, 番号 4. pp. 561-571.
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abstract = "Janus kinases (Jaks) play an important role in signal transduction via cytokine receptors. Tyk2 is a Janus kinase, and we developed tyk2-deficient mice to study the requirement for tyk2 in vivo. Tyk2-deficient mice show no overt developmental abnormalities; however, they display a lack of responsiveness to a small amount of IFNα, although a high concentration of IFNα can fully transduce its signal even in the absence of tyk2. Furthermore, IL-12-induced T cell function is defective in these mice. In contrast, these mice respond normally to IL-6 and IL-10, both of which activate tyk2 in vitro. These observations demonstrate that tyk2 plays only a restricted role in mediating IFNα-dependent signaling while being required in mediating IL-12-dependent biological responses.",
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T1 - Tyk2 plays a restricted role in IFNα signaling, although it is required for IL-12-mediated T cell function

AU - Shimoda, Kazuya

AU - Kato, Kouji

AU - Aoki, Kenichi

AU - Matsuda, Tadashi

AU - Miyamoto, Akitomo

AU - Shibamori, Masafumi

AU - Yamashita, Masakatsu

AU - Numata, Akihiko

AU - Takase, Ken

AU - Kobayashi, Shinji

AU - Shibata, Shouichirou

AU - Asano, Yoshinobu

AU - Gondo, Hisashi

AU - Sekiguchi, Kazuo

AU - Nakayama, Keiko

AU - Nakayama, Toshinori

AU - Okamura, Takashi

AU - Okamura, Seiichi

AU - Niho, Yoshiyuki

AU - Nakayama, Kei ichi

PY - 2000/1/1

Y1 - 2000/1/1

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AB - Janus kinases (Jaks) play an important role in signal transduction via cytokine receptors. Tyk2 is a Janus kinase, and we developed tyk2-deficient mice to study the requirement for tyk2 in vivo. Tyk2-deficient mice show no overt developmental abnormalities; however, they display a lack of responsiveness to a small amount of IFNα, although a high concentration of IFNα can fully transduce its signal even in the absence of tyk2. Furthermore, IL-12-induced T cell function is defective in these mice. In contrast, these mice respond normally to IL-6 and IL-10, both of which activate tyk2 in vitro. These observations demonstrate that tyk2 plays only a restricted role in mediating IFNα-dependent signaling while being required in mediating IL-12-dependent biological responses.

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