Ubiquitin enzymes in the regulation of immune responses

Petra Ebner, Gijs A. Versteeg, Fumiyo Ikeda

研究成果: Contribution to journalReview article

38 被引用数 (Scopus)


Ubiquitination plays a central role in the regulation of various biological functions including immune responses. Ubiquitination is induced by a cascade of enzymatic reactions by E1 ubiquitin activating enzyme, E2 ubiquitin conjugating enzyme, and E3 ubiquitin ligase, and reversed by deubiquitinases. Depending on the enzymes, specific linkage types of ubiquitin chains are generated or hydrolyzed. Because different linkage types of ubiquitin chains control the fate of the substrate, understanding the regulatory mechanisms of ubiquitin enzymes is central. In this review, we highlight the most recent knowledge of ubiquitination in the immune signaling cascades including the T cell and B cell signaling cascades as well as the TNF signaling cascade regulated by various ubiquitin enzymes. Furthermore, we highlight the TRIM ubiquitin ligase family as one of the examples of critical E3 ubiquitin ligases in the regulation of immune responses.

ジャーナルCritical Reviews in Biochemistry and Molecular Biology
出版ステータス出版済み - 7 4 2017

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

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