Ubiquitin enzymes in the regulation of immune responses

Petra Ebner, Gijs A. Versteeg, Fumiyo Ikeda

研究成果: ジャーナルへの寄稿評論記事

21 引用 (Scopus)

抄録

Ubiquitination plays a central role in the regulation of various biological functions including immune responses. Ubiquitination is induced by a cascade of enzymatic reactions by E1 ubiquitin activating enzyme, E2 ubiquitin conjugating enzyme, and E3 ubiquitin ligase, and reversed by deubiquitinases. Depending on the enzymes, specific linkage types of ubiquitin chains are generated or hydrolyzed. Because different linkage types of ubiquitin chains control the fate of the substrate, understanding the regulatory mechanisms of ubiquitin enzymes is central. In this review, we highlight the most recent knowledge of ubiquitination in the immune signaling cascades including the T cell and B cell signaling cascades as well as the TNF signaling cascade regulated by various ubiquitin enzymes. Furthermore, we highlight the TRIM ubiquitin ligase family as one of the examples of critical E3 ubiquitin ligases in the regulation of immune responses.

元の言語英語
ページ(範囲)425-460
ページ数36
ジャーナルCritical Reviews in Biochemistry and Molecular Biology
52
発行部数4
DOI
出版物ステータス出版済み - 7 4 2017
外部発表Yes

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Ubiquitin
Ubiquitination
Enzymes
Ubiquitin-Protein Ligases
Ubiquitin-Activating Enzymes
Ubiquitin-Conjugating Enzymes
Cell signaling
T-cells
Ligases
B-Lymphocytes
T-Lymphocytes
Substrates

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

これを引用

Ubiquitin enzymes in the regulation of immune responses. / Ebner, Petra; Versteeg, Gijs A.; Ikeda, Fumiyo.

:: Critical Reviews in Biochemistry and Molecular Biology, 巻 52, 番号 4, 04.07.2017, p. 425-460.

研究成果: ジャーナルへの寄稿評論記事

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