Ubiquitin ligases: Cell-cycle control and cancer

Keiichi Nakayama, Keiko Nakayama

研究成果: ジャーナルへの寄稿評論記事

921 引用 (Scopus)

抄録

A driving force of the cell cycle is the activation of cyclin-dependent kinases (CDKs), the activities of which are controlled by the ubiquitin-mediated proteolysis of key regulators such as cyclins and CDK inhibitors. Two ubiquitin ligases, the SKP1-CUL1-F-box-protein (SCF) complex and the anaphase-promoting complex/cyclosome (APC/C), are responsible for the specific ubiquitylation of many of these regulators. Deregulation of the proteolytic system might result in uncontrolled proliferation, genomic instability and cancer. Cumulative clinical evidence shows alterations in the ubiquitylation of cell-cycle regulators in the aetiology of many human malignancies. A better understanding of the ubiquitylation machinery will provide new insights into the regulatory biology of cell-cycle transitions and the development of anti-cancer drugs.

元の言語英語
ページ(範囲)369-381
ページ数13
ジャーナルNature Reviews Cancer
6
発行部数5
DOI
出版物ステータス出版済み - 5 1 2006

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Ubiquitination
Ligases
Ubiquitin
Cell Cycle Checkpoints
Cell Cycle
Cyclin-Dependent Kinases
F-Box Proteins
Anaphase-Promoting Complex-Cyclosome
Neoplasms
Cyclins
Genomic Instability
Proteolysis
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

Ubiquitin ligases : Cell-cycle control and cancer. / Nakayama, Keiichi; Nakayama, Keiko.

:: Nature Reviews Cancer, 巻 6, 番号 5, 01.05.2006, p. 369-381.

研究成果: ジャーナルへの寄稿評論記事

Nakayama, Keiichi ; Nakayama, Keiko. / Ubiquitin ligases : Cell-cycle control and cancer. :: Nature Reviews Cancer. 2006 ; 巻 6, 番号 5. pp. 369-381.
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