UDP-glucose: Ceramide glucosyltransferase (UGCG)

Yoshio Hirabayashi, Yohei Ishibashi

研究成果: 著書/レポートタイプへの貢献

1 引用 (Scopus)

抄録

Glycosphingolipids (GSLs) occur in most of all cell membranes of vertebrates and lower animals, as well as in plants. They are major component in lipid microdomains or lipid rafts to play important roles in a wide range of physiological and pathophysiological processes. Glucosylceramide (GlcCer) is a key precursor lipid for the synthesis of over 400 GSLs with different sugar chain structures (Fig. 1.1). In addition, GlcCer has unexpected function as hexose donor for the synthesis of cholesterylglucoside (Akiyama et al. 2011). GlcCer formation in the Golgi/ER membranes is catalyzed by the enzyme ceramide glucosyltransferase (GlcT-1/GCS/CEGT/UGCG). Since catalytic activity is detectable when mammalian GlcT-1 protein is expressed in E. coli, suggesting no requirement of protein co-factor for the expression of its activity (Ichikawa et al. 1996). The gene encoding GlcT-1 is highly conserved, and the knockout animals of the GlcT-1 gene proved essential roles in embryo development (Yamashita et al. 1999; Kohyama-Koganeya et al. 2004). However, little is known about why the knockout mouse dies at embryonic day 8 and how GlcT-1 activity is regulated.

元の言語英語
ホスト出版物のタイトルHandbook of Glycosyltransferases and Related Genes, Second Edition
出版者Springer Japan
ページ3-13
ページ数11
1
ISBN(電子版)9784431542407
ISBN(印刷物)9784431542391
DOI
出版物ステータス出版済み - 1 1 2014
外部発表Yes

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ceramide glucosyltransferase
Glucosylceramides
Glycosphingolipids
Lipids
Animals
Physiological Phenomena
Gene encoding
Hexoses
Essential Genes
Cell membranes
Knockout Mice
Sugars
Escherichia coli
Embryonic Development
Vertebrates
Catalyst activity
Proteins
Genes
Cell Membrane
Membranes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

これを引用

Hirabayashi, Y., & Ishibashi, Y. (2014). UDP-glucose: Ceramide glucosyltransferase (UGCG). : Handbook of Glycosyltransferases and Related Genes, Second Edition (巻 1, pp. 3-13). Springer Japan. https://doi.org/10.1007/978-4-431-54240-7_53

UDP-glucose : Ceramide glucosyltransferase (UGCG). / Hirabayashi, Yoshio; Ishibashi, Yohei.

Handbook of Glycosyltransferases and Related Genes, Second Edition. 巻 1 Springer Japan, 2014. p. 3-13.

研究成果: 著書/レポートタイプへの貢献

Hirabayashi, Y & Ishibashi, Y 2014, UDP-glucose: Ceramide glucosyltransferase (UGCG). : Handbook of Glycosyltransferases and Related Genes, Second Edition. 巻. 1, Springer Japan, pp. 3-13. https://doi.org/10.1007/978-4-431-54240-7_53
Hirabayashi Y, Ishibashi Y. UDP-glucose: Ceramide glucosyltransferase (UGCG). : Handbook of Glycosyltransferases and Related Genes, Second Edition. 巻 1. Springer Japan. 2014. p. 3-13 https://doi.org/10.1007/978-4-431-54240-7_53
Hirabayashi, Yoshio ; Ishibashi, Yohei. / UDP-glucose : Ceramide glucosyltransferase (UGCG). Handbook of Glycosyltransferases and Related Genes, Second Edition. 巻 1 Springer Japan, 2014. pp. 3-13
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