Understanding intratumor heterogeneity by combining genome analysis and mathematical modeling

Atsushi Niida, Satoshi Nagayama, Satoru Miyano, Koshi Mimori

研究成果: Contribution to journalReview article査読

19 被引用数 (Scopus)

抄録

Cancer is composed of multiple cell populations with different genomes. This phenomenon called intratumor heterogeneity (ITH) is supposed to be a fundamental cause of therapeutic failure. Therefore, its principle-level understanding is a clinically important issue. To achieve this goal, an interdisciplinary approach combining genome analysis and mathematical modeling is essential. For example, we have recently performed multiregion sequencing to unveil extensive ITH in colorectal cancer. Moreover, by employing mathematical modeling of cancer evolution, we demonstrated that it is possible that this ITH is generated by neutral evolution. In this review, we introduce recent advances in a research field related to ITH and also discuss strategies for exploiting novel findings on ITH in a clinical setting.

本文言語英語
ページ(範囲)884-892
ページ数9
ジャーナルCancer Science
109
4
DOI
出版ステータス出版済み - 4 2018
外部発表はい

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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